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A regioselective synthesis of imidazothiazolotriazines based on the cyclization of imidazotriazinethiones with phenacyl bromides

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Chemistry of Heterocyclic Compounds Aims and scope

Novel imidazothiazolotriazines were obtained as a result of the reaction of imidazo[4,5-e][1,2,4]triazine-3-thiones with various phenacyl bromides. It was shown that the cyclocondensation proceeds with high regioselectivity leading to the formation of linear 7-arylimidazo-[4,5-e]thiazolo[3,2-b][1,2,4]triazines.

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This study was financially supported by the Grants Council of the President of the Russian Federation for the State support of young Russian scientists (project MK-2375.2022.1.3).

The X-ray structural analysis and registration of highresolution mass spectra were performed at the Department of Structural Research of N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences (Moscow).

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  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow, 119991, Russia

    Dmitry B. Vinogradov, Alexei N. Izmest’ev, Angelina N. Kravchenko & Galina А. Gazieva

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  1. Dmitry B. Vinogradov
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  2. Alexei N. Izmest’ev
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  3. Angelina N. Kravchenko
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  4. Galina А. Gazieva
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Correspondence to Galina А. Gazieva.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2022, 58(10), 524–530

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Vinogradov, D.B., Izmest’ev, A.N., Kravchenko, A.N. et al. A regioselective synthesis of imidazothiazolotriazines based on the cyclization of imidazotriazinethiones with phenacyl bromides. Chem Heterocycl Comp 58, 524–530 (2022). https://doi.org/10.1007/s10593-022-03123-5

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  • DOI: https://doi.org/10.1007/s10593-022-03123-5

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