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Synthesis of 2,5-disubstituted pyrazolyl-1,3,4-oxadiazoles by the Huisgen reaction

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Abstract

We developed an approach to the synthesis of 2,5-disubstituted pyrazole-containing 1,3,4-oxadiazoles by acylation of 5-(nitropyrazolyl)tetrazoles with alkyl, aryl, and hetaryl acyl chlorides with subsequent recyclization of the intermediate N-acyltetrazoles into 1,3,4-oxadiazoles and studied nitration of the obtained 2-aryl-5-(nitropyrazolyl)-1,3,4-oxadiazoles.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    T. K. Shkineva, O. V. Serushkina, I. A. Vatsadze, T. E. Khoranyan & I. L. Dalinger

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  1. T. K. Shkineva
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  2. O. V. Serushkina
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  3. I. A. Vatsadze
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  4. T. E. Khoranyan
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Correspondence to I. L. Dalinger.

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Dedicated to the Academician of the Russian Academy of Sciences V. A. Tartakovsky on the occasion of his 90th birthday.

No human or animal subjects were used in this research.

The authors declare no competing interests.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1737–1744, August, 2022.

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Shkineva, T.K., Serushkina, O.V., Vatsadze, I.A. et al. Synthesis of 2,5-disubstituted pyrazolyl-1,3,4-oxadiazoles by the Huisgen reaction. Russ Chem Bull 71, 1737–1744 (2022). https://doi.org/10.1007/s11172-022-3584-1

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