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Effective synthesis of 7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines

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Chemistry of Heterocyclic Compounds Aims and scope

A highly effective method for the preparation of 7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines was developed on the basis of condensation reaction between aryl(hetaryl) α-bromo ketones and commercially available thiocarbohydrazide, followed by treatment of the obtained 2-hydrazinyl-6H-1,3,4-thiadiazine hydrobromides with ortho esters in the presence of trifluoroacetic acid under mild conditions.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow, 119991, Russia

    Alexander S. Kulikov, Margarita A. Epishina, Leonid L. Fershtat & Nina N. Makhova

Authors
  1. Alexander S. Kulikov
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  2. Margarita A. Epishina
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  3. Leonid L. Fershtat
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  4. Nina N. Makhova
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Corresponding author

Correspondence to Nina N. Makhova.

Additional information

A Supplementary information file containing 1Н and 13С NMR spectra of all obtained compounds is available at the journal website at http://link.springer.com/journal/10593.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2018, 54(6), 669–672

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Kulikov, A.S., Epishina, M.A., Fershtat, L.L. et al. Effective synthesis of 7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines. Chem Heterocycl Comp 54, 669–672 (2018). https://doi.org/10.1007/s10593-018-2325-8

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  • DOI: https://doi.org/10.1007/s10593-018-2325-8

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