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One-step synthesis of 1,4-bis(het)arylisoquinolines by the reaction of 1,2,4-triazines with arynes

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Chemistry of Heterocyclic Compounds Aims and scope

The reaction of 3,6-bis(het)aryl-1,2,4-triazines (hetaryl ≠ 2-pyridyl) with aryne intermediates generated in situ was studied. As a result, novel 1,4-bis(het)arylisoquinolines were synthesized with yields of up to 45%. The main rules of the reactions were studied, and the obtained experimental data were compared with those described in the literature.

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This work was supported by the Russian Science Foundation (grant 18-13-00365).

Elemental analysis was performed by the elemental analysis group of the Postovsky Institute of Organic Synthesis.

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Authors and Affiliations

  1. Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St, Yekaterinburg, 620002, Russia

    Dmitry S. Kopchuk, Igor L. Nikonov, Albert F. Khasanov, Sravya Gundala, Alexey P. Krinochkin, Pavel А. Slepukhin, Grigory V. Zyryanov, Oleg N. Chupakhin & Valery N. Charushin

  2. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoi / 20 Akademicheskaya St, Yekaterinburg, 620990, Russia

    Dmitry S. Kopchuk, Igor L. Nikonov, Albert F. Khasanov, Alexey P. Krinochkin, Pavel А. Slepukhin, Grigory V. Zyryanov, Oleg N. Chupakhin & Valery N. Charushin

  3. Sri Venkateswara University, Tirupati, Andhra Pradesh, 517502, India

    Padmavathi Venkatapuram

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  1. Dmitry S. Kopchuk
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  2. Igor L. Nikonov
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  3. Albert F. Khasanov
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  5. Alexey P. Krinochkin
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  6. Pavel А. Slepukhin
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  8. Padmavathi Venkatapuram
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  9. Oleg N. Chupakhin
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  10. Valery N. Charushin
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Correspondence to Grigory V. Zyryanov.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2019, 55(10), 978–984

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Kopchuk, D.S., Nikonov, I.L., Khasanov, A.F. et al. One-step synthesis of 1,4-bis(het)arylisoquinolines by the reaction of 1,2,4-triazines with arynes. Chem Heterocycl Comp 55, 978–984 (2019). https://doi.org/10.1007/s10593-019-02565-8

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  • DOI: https://doi.org/10.1007/s10593-019-02565-8

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