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4-Hydroxy-2-quinolones. 195*. Synthesis of novel, potential analgesics based on 4-(hetarylmethyl)amino-2-oxo-1,2-dihydro-quinoline-3-carboxylic acids

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Chemistry of Heterocyclic Compounds Aims and scope

From the viewpoint of the method of bioisosteric replacement we have carried out the synthesis of a series of 4-(hetarylmethyl)amino-2-oxo-1,2-dihydroquinoline-3-carboxylic acids. For several examples it has been shown experimentally that the aromatic ring in the benzyl fragment of 4-benzylamino-2-oxo-1,2-dihydroquinoline-3-carboxylic acid can be replaced by an isosteric heterocycle without lowering the analgesic properties.

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Authors and Affiliations

  1. National Pharmaceutical University, Kharkiv, 61002, Pushkin Str., 53, Ukraine

    I. V. Ukrainets

  2. Institute of Chemical Technology, V. Dal East-Ukrainian National University, Lenin Str., 31, Rubizhne, 93003, Ukraine

    E. V. Mospanova

  3. Luhansk State Medical University, 1 Kvartal 50-richia Oborony Luhanska, Luhansk, 91045, Ukraine

    L. V. Savchenkova & S. I. Yankovich

Authors
  1. I. V. Ukrainets
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  2. E. V. Mospanova
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  3. L. V. Savchenkova
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  4. S. I. Yankovich
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Corresponding author

Correspondence to I. V. Ukrainets.

Additional information

*For Communication 194, see [1].

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 90–97, January, 2011.

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Ukrainets, I.V., Mospanova, E.V., Savchenkova, L.V. et al. 4-Hydroxy-2-quinolones. 195*. Synthesis of novel, potential analgesics based on 4-(hetarylmethyl)amino-2-oxo-1,2-dihydro-quinoline-3-carboxylic acids. Chem Heterocycl Comp 47, 67–73 (2011). https://doi.org/10.1007/s10593-011-0721-4

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  • DOI: https://doi.org/10.1007/s10593-011-0721-4

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