Abstract
Glaucoma is a group of diseases characterized by the degeneration of retinal ganglion cells (RGCs) and progressive, irreversible vision loss. High intraocular pressure (IOP) heightens the likelihood of glaucoma and correlates with RGC loss. While the current glaucoma therapy prioritizes lower the IOP; however, RGC, and visual loss may persist even when the IOP is well-controlled. As such, discovering and creating IOP-independent neuroprotective strategies for safeguard RGCs is crucial for glaucoma management. Investigating and clarifying the mechanism behind RGC death to counteract its effects is a promising direction for glaucoma control. Empirical studies of glaucoma reveal the role of multiple regulated cell death (RCD) pathways in RGC death. This review delineates the RCD of RGCs following IOP elevation and optic nerve damage and discusses the substantial benefits of mitigating RCD in RGCs in preserving visual function.
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References
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Acknowledgements
The authors would like to acknowledge the language-editing service provided by EditorBar Co., and Dr. Piniel Alphayo Kambey in Xuzhou Medical Uninversity.
Funding
This work was supported by National Natural Science Foundation of China (81971891, 82172196, and 81772134), Key Laboratory of Emergency and Trauma of Ministry of Education (Hainan Medical University) (KLET-202210), and the College Students’ Innovation and Entrepreneurship Project (S20210026020013).
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KX and QZ were the major contributors to design the study. WZ was the major contributor to manuscript writing, and figures creating. CF, XH, XB and YH assisted in the literature search and data analysis. HW and QZ edited the manuscript. QZ, KX, WZ and CF were major contributors to manuscript revision. All authors have read and approved the final manuscript.
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Zhao, Wj., Fan, Cl., Hu, Xm. et al. Regulated Cell Death of Retinal Ganglion Cells in Glaucoma: Molecular Insights and Therapeutic Potentials. Cell Mol Neurobiol 43, 3161–3178 (2023). https://doi.org/10.1007/s10571-023-01373-1
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DOI: https://doi.org/10.1007/s10571-023-01373-1