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Ag Nanoparticles Stabilized on Magnetic Carboxymethyl Lignin: Synthesis, Characterization and its Performance in the N-Acylation Reactions and Investigation of its Antioxidant and Anti-Human Colorectal Cancer Application

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Abstract

This report expresses a sustainable methodology for the in situ synthesis of Ag nanoparticles (NPs) adorned carboxymethyl lignin (CML) functionalized Fe3O4 nanocomposite (Fe3O4@CML/Ag) and its subsequent chemical and biological applications. Structural and physicochemical features of such novel material was evaluated through a number of analytical techniques like FT-IR, FE-SEM, TEM, EDS, XRD, ICP and VSM. The nanomaterial was a competent catalyst towards the N-acylation of diverse amines using acetic anhydride at solvent-free conditions. The material was isolated by magnet and reused for 8 consecutive times. Furthermore, the material was employed in the biological evaluation of anti-oxidant properties by DPPH method as well as the anticancer studies of against HT-29 and Caco-2 colon cell lines following MTT method. The DPPH assay afforded a significant IC50 value that suggested the material to have good anticancer properties. Interestingly, % cell viability of the malignant cell lines was found to decrease dose-dependently over Fe3O4@NaLS/Ag nanocomposite. MTT assay afforded the corresponding IC50 values to be 395.4 μg/ml and 287.3 μg/ml respectively against the two cell lines. The absorbance rate was evaluated at 545 nm, which represented toxicity on normal cell line (CHO) even up to 2000 μg/mL.

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Acknowledgements

The authors would like to extend their appreciation to Deanship of Scientific Research at King Khalid University for funding this project through the General Research Program under grant number (R.G.P2/197/43).

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Authors and Affiliations

  1. Department of Gastrointestinal Surgery, Hanzhong 3201 hospital, Hanzhong, 723000, China

    Yadong Zhou & Fafu Dou

  2. Department of Chemistry, Gobardanga Hindu College, 24 Parganas (North), India

    Bikash Karmakar

  3. Department of Biology, College of Science, King Khalid University, Abha, 61421, Saudi Arabia

    Attalla F. El-kott & Fatimah A. Al-Saeed

  4. Department of Zoology, College of Science, Damanhour University, Damanhour, 22511, Egypt

    Attalla F. El-kott

  5. Department of Life Sciences, College of Science and Art Mahyel Aseer, King Khalid University, Abha, 62529, Saudi Arabia

    Sally Negm

  6. Unit of Food Bacteriology, Central Laboratory of Food Hygiene, Ministry of Health, Branch in Zagazig, Zagazig, 44511, Egypt

    Sally Negm

  7. Department of Anatomy, College of Medicine, King Khalid University, Post Office Box: 960, Abha, 61421, Saudi Arabia

    Eman M. El Nashar

  8. Department of Histology and Cell Biology College of Medicine, Benha University, Benha, Egypt

    Eman M. El Nashar

  9. Department of Basic Science, Faculty of Physical Therapy, Horus University-Egypt, New Damietta, 34518, Egypt

    Eman T. Salem

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  1. Yadong Zhou
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Zhou, Y., Karmakar, B., Dou, F. et al. Ag Nanoparticles Stabilized on Magnetic Carboxymethyl Lignin: Synthesis, Characterization and its Performance in the N-Acylation Reactions and Investigation of its Antioxidant and Anti-Human Colorectal Cancer Application. Catal Lett 154, 409–421 (2024). https://doi.org/10.1007/s10562-023-04310-5

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