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Kinetics and Mechanism Investigation of the Synthesized Highly Diasteroselective Substituted Tetrahydropyridines in the Presence of La(NO3)3.6H2O as a Catalyst

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Abstract

For the first time, kinetics and mechanism of reaction between 4-methyl-benzaldehyde, 4-bromoaniline and methyl acetoacetate is spectrally investigated in the presence of La(NO3)3.6H2O as a catalyst. Based on the experiment data, the overall order of the reaction is two. The second-order rate constant dependency on the temperature was in agreement with the Arrhenius and Eyring equations. The kinetic and thermodynamic parameters of the reaction have been calculated. Furthermore, useful information was obtained from studies of the effect of solvent and concentration of reactants on the reaction rate. The results showed that the second step of the reaction mechanism is a rate-determining step (RDS). The proposed mechanism was also confirmed according to the obtained results and the steady state approximation.

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Acknowledgments

We gratefully acknowledge financial support from the Research Council of the University of Sistan and Baluchestan.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P O Box 98135-674, Zahedan, Iran

    Maryam Dehdab, SayyedMostafa Habibi-Khorassani & Mehdi Shahraki

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  1. Maryam Dehdab
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  2. SayyedMostafa Habibi-Khorassani
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  3. Mehdi Shahraki
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Correspondence to SayyedMostafa Habibi-Khorassani.

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Dehdab, M., Habibi-Khorassani, S. & Shahraki, M. Kinetics and Mechanism Investigation of the Synthesized Highly Diasteroselective Substituted Tetrahydropyridines in the Presence of La(NO3)3.6H2O as a Catalyst. Catal Lett 144, 1790–1796 (2014). https://doi.org/10.1007/s10562-014-1338-x

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