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α-Zirconium Sulfophenylphosphonate as a Catalyst for the Synthesis of 3,4-Dihydropyrimidin-2(1H)-One Derivatives Under Solvent Free Conditions

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Abstract

3,4-Dihydropyrimidin-2(1H)-one derivatives were synthesized using layered α-zirconium sulfophenylphosphonate as a recyclable heterogeneous catalyst. Several classes of reagents, such as functionalized aromatic and aliphatic aldehydes, β-dicarbonyl derivatives and 2-aminobenzimidazole, were used to synthesize different 3,4-dihydropyrimidin-2(1H)-one derivatives under solvent free conditions.

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Acknowledgment

Financial support from MIUR, National Project 2008 “Approccio ecocompatibile all’intensificazione di processo nella sintesi organica” is gratefully acknowledged.

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Authors and Affiliations

  1. Dipartimento di Chimica e Tecnologia del Farmaco, Università degli Studi, via del Liceo 1, 06123, Perugia, Italy

    Ornelio Rosati, Massimo Curini & Francesca Montanari

  2. Dipartimento di Chimica, Università degli Studi, Via Elce di Sotto 8, 06123, Perugia, Italy

    Morena Nocchetti

  3. Dipartimento di Scienze del Farmaco, Università G. D’Annunzio, Via dei Vestini 31, 66100, Chieti, Italy

    Salvatore Genovese

Authors
  1. Ornelio Rosati
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  2. Massimo Curini
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  3. Francesca Montanari
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  4. Morena Nocchetti
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  5. Salvatore Genovese
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Correspondence to Ornelio Rosati.

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Rosati, O., Curini, M., Montanari, F. et al. α-Zirconium Sulfophenylphosphonate as a Catalyst for the Synthesis of 3,4-Dihydropyrimidin-2(1H)-One Derivatives Under Solvent Free Conditions. Catal Lett 141, 850–853 (2011). https://doi.org/10.1007/s10562-011-0604-4

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