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Cardiac magnetic resonance imaging (CMR) has long been recognized as an accurate and reliable means of evaluating cardiac anatomy and ventricular function. Considerable progress has been made in the field of CMR, providing accurate evaluation of myocardial ischemia and infarction [1, 2]. Contrast-enhanced CMR can be used to visualize the transmural extent of myocardial infarction with high spatial resolution [3–5]. Infarcted myocardium appears hyperenhanced compared with normal myocardium when imaged by a delayed-enhancement MRI technique with the use of T1-weighted sequence after injection of gadolinium chelates. Late gadolinium-enhanced CMR can clearly delineate subendocardial infarction and the transmural extent of delayed enhancement potentially predicts functional outcome after revascularization in acute myocardial infarction and chronic ischemic heart disease. This indicates that the late enhancement technique can accurately discriminate between infarction and dysfunctional but viable myocardium. Experimental and clinical studies have shown that the extent of delayed enhancement is reproducible and closely correlates with the size of myocardial necrosis or infarct scar as determined by established in vitro and in vivo methods. Furthermore, CMR appears to be more sensitive than other imaging methods in detecting small subendocardial infarctions.
Stress first-pass contrast-enhanced myocardial perfusion CMR can be used to detect subendocardial ischemia [6, 7], and recent studies have demonstrated the high diagnostic accuracy of stress myocardial perfusion CMR for detecting significant coronary artery disease. Free-breathing, whole-heart coronary angiography (MRA) was recently introduced as a method that can provide visualization of all three major coronary arteries and coronary bypasses within a single three-dimensional acquisition [8]. With further improvements in CMR techniques and the establishment of a standardized study protocol, CMR will play a pivotal role in imaging patients with ischemic heart disease.
In recent years, late gadolinium enhancement CMR has also been used to visualize myocardial interstitial abnormalities. Studies by the groups of Pennell et al. and Sechtem et al. [9–12] have clearly shown late enhancement patterns in patients with different forms of cardiomyopathies, amyloidosis, myocarditis, storage diseases etc. Silva et al. [10] showed that late enhancement can be demonstrated in cardiomyopathy patients, with a mean signal intensity of 390 ± 220% compared with normal regions. The distribution pattern of late enhancement was unlike the subendocardial late enhancement related to coronary territories found in myocardial infarction. The affected areas included papillary muscles (sarcoid), the mid-myocardium (Anderson–Fabry disease, glycogen storage disease, myocarditis, Becker muscular dystrophy) and the global subendocardium (systemic sclerosis, Loeffler’s endocarditis, amyloid, Churg-Strauss). Focal myocardial late gadolinium enhancement is found in the specific cardiomyopathies, and the pattern is distinct from that seen in myocardial infarction. Vogelsberg et al. [12] showed in patients with biopsy-proven cardiac amyloidosis, that late gadolinium enhancement frequently occurs in a peculiar pattern. Consequently, noninvasive CMR can be used to diagnose or rule out cardiac amyloidosis with good sensitivity and excellent specificity in a clinical routine setting. In a recent study Hartke et al. [13] demonstrated right ventricular late gadolinium enhancement in patients with congenital heart disease and right ventricular loading conditions. Clinical variables were associated with the presence of fibrosis but did not reliably predict severity. Myocardial preservation is likely a multifactorial process that may affect the right and left ventricles differently [14].
In an article in the present issue, Bohl et al. [15] aim to systematically categorize late enhancement patterns in a variety of non-ischemic heart diseases and to explore their relationship with left ventricular function. The authors evaluated 156 patients with NIHD who exhibited late enhancement on CMR. Late enhancement was correlated to left ventricular function. It was clearly shown that late enhancement spared the subendocardium. Consistent late enhancement patterns were observed in myocarditis, hypertrophic and dilated cardiomyopathy and systemic vasculitis. No conclusive late enhancement patterns were observed in patients with aortic stenosis, arterial hypertension, lupus erythematosus, sarcoidosis, ventricular arrhythmia and in a mixed subgroup of rare non-ischemic heart diseases. There was no significant relationship between late enhancement and ejection fraction. There was no correlation between end diastolic volume and late enhancement in either myocarditis or dilated cardiomyopathy. Late enhancement was unrelated to left ventricular mass in aortic stenosis and hypertrophic cardiomyopathy.
This interesting study therefore proposed a methodological approach with which to describe and categorize late enhancement in patients with non-ischemic heart diseases. Distinct late enhancement patterns were demonstrated in four of the investigated subgroups with non-ischemic heart disease i.e. myocarditic type, dilated cardiomyopathy type, hypertrophic cardiomyopathy type and vasculitic type. A number of rare late enhancement phenotypes were elucidated that had not been described yet. Finally, it was shown that the extent of tissue injury in non-ischemic heart disease is, unlike in coronary artery disease, largely independent of systolic left ventricular function. Unlike in ischemic heart disease, the structure–function relationship did not appear to be strong. As the authors correctly state, a variety of myocardial tissue alterations occur, all of which may provide candidate substrates for positive late enhancement. Although late enhancement studies in non-ischemic heart disease are very encouraging, more sophisticated CMR techniques and prognostic clinical studies are warranted to understand the true underlying mechanisms and consequences of late myocardial contrast enhancement.
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Open Access This is an open access article distributed under the terms of the Creative Commons Attribution Noncommercial License (https://creativecommons.org/licenses/by-nc/2.0), which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
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van der Wall, E.E., Bax, J.J. Late contrast enhancement by CMR: more than scar?. Int J Cardiovasc Imaging 24, 609–611 (2008). https://doi.org/10.1007/s10554-008-9312-6
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DOI: https://doi.org/10.1007/s10554-008-9312-6