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Protein-based microneedles for biomedical applications: A systematic review

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Abstract

Microneedles are minimally-invasive devices with the unique capability of bypassing physiological barriers. Hence, they are widely used for different applications from drug/vaccine delivery to diagnosis and cosmetic fields. Recently, natural biopolymers (particularly carbohydrates and proteins) have garnered attention as safe and biocompatible materials with tailorable features for microneedle construction. Several review articles have dealt with carbohydrate-based microneedles. This review aims to highlight the less-noticed role of proteins through a systematic search strategy based on the PRISMA guideline from international databases of PubMed, Science Direct, Scopus, and Google Scholar. Original English articles with the keyword “microneedle(s)” in their titles along with at least one of the keywords “biopolymers, silk, gelatin, collagen, zein, keratin, fish-scale, mussel, and suckerin” were collected and those in which the proteins undertook a structural role were screened. Then, we focused on the structures and applications of protein-based microneedles. Also, the unique features of some protein biopolymers that make them ideal for microneedle construction (e.g., excellent mechanical strength, self-adhesion, and self-assembly), as well as the challenges associated with them were reviewed. Altogether, the proteins identified so far seem not only promising for the fabrication of “better” microneedles in the future but also inspiring for designing biomimetic structural biopolymers with ideal characteristics.

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References

  • A. Aditya, B. Kim, R.D. Koyani, B. Oropeza, M. Furth, J. Kim, N.P. Kim, J. Drug. Deliv. Sci. Technol. 52, 618 (2019)

    Article  CAS  Google Scholar 

  • S. Afewerki, A. Sheikhi, S. Kannan, S. Ahadian, A. Khademhosseini, Bioeng. Transl. Med. 4, 96 (2019)

    Article  CAS  PubMed  Google Scholar 

  • A. Ahmady, N.H.A. Samah, Int. J. Pharm. 608, 121037 (2021)

    Article  CAS  PubMed  Google Scholar 

  • A. Aksit, S. Rastogi, M.L. Nadal, A.M. Parker, A.K. Lalwani, A.C. West, J.W. Kysar, Drug Deliv. Transl. Res. 11, 214 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • G.H. Altman, F. Diaz, C. Jakuba, T. Calabro, R.L. Horan, J. Chen, H. Lu, J. Richmond, D.L. Kaplan, Biomaterials 24, 401 (2003)

    Article  CAS  PubMed  Google Scholar 

  • R. Amarnani, P. Shende, Biomed. Microdevice 24, 1 (2022)

    Article  Google Scholar 

  • M.S. Arshad, S. Zafar, A.T. Zahra, M.H. Zaman, A. Akhtar, I. Kucuk, M. Farhan, M.-W. Chang, Z. Ahmad, J. Drug Target. 29, 60 (2021)

    Article  CAS  PubMed  Google Scholar 

  • M. Avcil, A. Çelik, Micromachines 12, 1321 (2021)

    Article  PubMed  PubMed Central  Google Scholar 

  • T. Baydin, O.A. Aarstad, M.J. Dille, M.N. Hattrem, K.I. Draget, Food Hydrocolloids 127, 107535 (2022)

    Article  CAS  Google Scholar 

  • R.S. Bhadale, V.Y. Londhe, J. Mater. Sci. - Mater. Med. 32, 1 (2021)

    Article  Google Scholar 

  • S. Bhatnagar, S.R. Chawla, O.P. Kulkarni, V.V.K. Venuganti, ACS Omega 2, 1321 (2017)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • S. Bhatnagar, P.R. Gadeela, P. Thathireddy, V.V.K. Venuganti, J. Chem. Sci. 131, 1 (2019)

    Article  CAS  Google Scholar 

  • S. Bhatnagar, P. Kumari, S.P. Pattarabhiran, V.V.K. Venuganti, AAPS Pharm. Sci. Tech. 19, 1818 (2018)

    Article  CAS  Google Scholar 

  • E. Caffarel-Salvador, S. Kim, V. Soares, R.Y. Tian, S.R. Stern, D. Minahan, R. Yona, X. Lu, F.R. Zakaria, J. Collins, Sci. Adv. 7, eabe2620 (2021)

    Article  ADS  CAS  PubMed  Google Scholar 

  • R. Chambers, Biol. Bull. 41, 318 (1921)

    Article  Google Scholar 

  • H. Chang, M. Zheng, X. Yu, A. Than, R.Z. Seeni, R. Kang, J. Tian, D.P. Khanh, L. Liu, P. Chen, C. Xu, Adv. Mater. 29, 1702243 (2017)

    Article  Google Scholar 

  • B. Chen, J. Wei, C. Iliescu, Sens. Actuators, B Chem. 145, 54 (2010)

    Article  CAS  Google Scholar 

  • B.Z. Chen, M. Ashfaq, D.D. Zhu, X.P. Zhang, X.D. Guo, Macromol. Rapid Commun. 39, e1800075 (2018a)

    Article  PubMed  Google Scholar 

  • B.Z. Chen, Z.Q. Zhao, M.-A. Shahbazi, X.D. Guo, Nanoscale Horizons 7, 715 (2022a)

    Article  ADS  CAS  PubMed  Google Scholar 

  • S. Chen, H. Matsumoto, Y. Moro-Oka, M. Tanaka, Y. Miyahara, T. Suganami, A. Matsumoto, ACS Biomater. Sci. Eng. 5, 5781 (2019)

    Article  CAS  PubMed  Google Scholar 

  • W. Chen, J. Wainer, S.W. Ryoo, X. Qi, R. Chang, J. Li, S.H. Lee, S. Min, A. Wentworth, J.E. Collins, Sci. Adv. 8, eabk1792 (2022b)

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  • Y.-H. Chen, D.-C. Lin, E. Chern, Y.-Y. Huang, Biomed. Microdevice 22, 1 (2020)

    Article  Google Scholar 

  • Z. Chen, Q. Hu, Z. Gu, Acc. Chem. Res. 51, 668 (2018b)

    Article  CAS  PubMed  Google Scholar 

  • N. Dabholkar, S. Gorantla, T. Waghule, V.K. Rapalli, A. Kothuru, S. Goel, G. Singhvi, Int. J. Biol. Macromol. 170, 602 (2021)

    Article  CAS  PubMed  Google Scholar 

  • F. Damiri, N. Kommineni, S.O. Ebhodaghe, R. Bulusu, V.G.S. Jyothi, A.A. Sayed, A.A. Awaji, M.O. Germoush, H.S. Al-Malky, M.Z. Nasrullah, Pharmaceuticals 15, 190 (2022)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • P.C. DeMuth, Y. Min, D.J. Irvine, P.T. Hammond, Adv. Healthcare Mater. 3, 47 (2014)

    Article  CAS  Google Scholar 

  • D. Ding, J. Pan, S.H. Lim, S. Amini, L. Kang, A. Miserez, Journal of Materials Chemistry B 5, 8467 (2017)

    Article  CAS  PubMed  Google Scholar 

  • R.V. Dixon, E. Skaria, W.M. Lau, P. Manning, M.A. Birch-Machin, S.M. Moghimi, K.W. Ng, Acta Pharmaceutica Sinica B 11, 2344 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • R.F. Donnelly, M. J. Garland, and A. Z. Alkilani, Drug Deliv. Sys. 121 (2014)

  • S. Early, I.S. Moon, K. Bommakanti, I. Hunter, K.M. Stankovic, Hear. Res. 381, 107761 (2019)

    Article  PubMed  Google Scholar 

  • Ö. Erdem, I. Eş, G.A. Akceoglu, Y. Saylan, F. Inci, Biosensors 11, 296 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • D.F. Fonseca, P.C. Costa, I.F. Almeida, P. Dias-Pereira, I. Correia-Sá, V. Bastos, H. Oliveira, C. Vilela, A.J. Silvestre, C.S. Freire, Macromol. Biosci. 20, 2000195 (2020)

    Article  CAS  Google Scholar 

  • D.F.S. Fonseca, C. Vilela, A.J.D. Silvestre, C.S.R. Freire, Int. J. Biol. Macromol. 136, 704 (2019)

    Article  CAS  PubMed  Google Scholar 

  • M. Foox, M. Zilberman, Expert Opin. Drug Deliv. 12, 1547 (2015)

    Article  CAS  PubMed  Google Scholar 

  • M. Furtado, L. Chen, Z. Chen, A. Chen, W. Cui, Eng. Regen. 3, 217 (2022)

    Google Scholar 

  • B. Gao, M. Guo, K. Lyu, T. Chu, B. He, Adv. Func. Mater. 31, 2006839 (2021)

    Article  CAS  Google Scholar 

  • Y. Gao, M. Hou, R. Yang, L. Zhang, Z. Xu, Y. Kang, P. Xue, Biomacromol 20, 1334 (2019a)

    Article  CAS  Google Scholar 

  • Y. Gao, M. Hou, R. Yang, L. Zhang, Z. Xu, Y. Kang, P. Xue, J Mater Chem B 7, 7515 (2019b)

    Article  CAS  PubMed  Google Scholar 

  • M. S. Gerstel and V. A. Place, US Patent No. US3964482A (1976)

  • J. Gorham, Quart. J. Sci. Lit. Art 2, 206 (1821)

    Google Scholar 

  • S. Grabska-Zielińska, A. Sionkowska, Materials 14, 1510 (2021)

    Article  ADS  PubMed  PubMed Central  Google Scholar 

  • A.J. Guillot, A.S. Cordeiro, R.F. Donnelly, M.C. Montesinos, T.M. Garrigues, A. Melero, Pharmaceutics 12, 569 (2020)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • S. Henry, D.V. McAllister, M.G. Allen, M.R. Prausnitz, J. Pharm. Sci. 87, 922 (1998)

    Article  CAS  PubMed  Google Scholar 

  • S.H. Hiew, P.A. Guerette, O.J. Zvarec, M. Phillips, F. Zhou, H. Su, K. Pervushin, B.P. Orner, A. Miserez, Acta Biomater. 46, 41 (2016)

    Article  CAS  PubMed  Google Scholar 

  • P. Hill, H. Brantley, M. Van Dyke, Biomaterials 31, 585 (2010)

    Article  CAS  PubMed  Google Scholar 

  • C. Holland, K. Numata, J. Rnjak-Kovacina, F.P. Seib, Adv. Healthcare Mater. 8, 1800465 (2019)

    Article  Google Scholar 

  • M.K. Hossain, T. Ahmed, P. Bhusal, R.K. Subedi, I. Salahshoori, M. Soltani, M. Hassanzadeganroudsari, Expert Rev. Vaccines 19, 1153 (2020)

    Article  CAS  PubMed  Google Scholar 

  • O. Howells, N. Rajendran, S. Mcintyre, S. Amini-Asl, P. Henri, Y. Liu, O. Guy, A.E. Cass, M.C. Morris, S. Sharma, ChemBioChem 20, 2198 (2019)

    Article  CAS  PubMed  Google Scholar 

  • S. Hu, X. Pei, L. Duan, Z. Zhu, Y. Liu, J. Chen, T. Chen, P. Ji, Q. Wan, J. Wang, Nat. Commun. 12, 1 (2021a)

    Article  ADS  Google Scholar 

  • X. Hu, H. Zhang, Z. Wang, C.Y.A. Shiu, Z. Gu, Small Structures 2, 2000097 (2021b)

    Article  Google Scholar 

  • Y. Huang, H. Yu, L. Wang, D. Shen, Z. Ni, S. Ren, Y. Lu, X. Chen, J. Yang, and Y. Hong, Eur. Polym. J. 110942 (2021)

  • R.S. Ingrole, E. Azizoglu, M. Dul, J.C. Birchall, H.S. Gill, M.R. Prausnitz, Biomaterials 267, 120491 (2021)

    Article  CAS  PubMed  Google Scholar 

  • E. Jamróz, Biopolymeric Nanomaterials. 423 (2021)

  • E.Y. Jeon, J. Lee, B.J. Kim, K.I. Joo, K.H. Kim, G. Lim, H.J. Cha, Biomaterials 222, 119439 (2019)

    Article  CAS  PubMed  Google Scholar 

  • C. Jiang, X. Wang, R. Gunawidjaja, Y.-H. Lin, M.K. Gupta, D.L. Kaplan, R.R. Naik, V.V. Tsukruk, Adv. Func. Mater. 17, 2229 (2007)

    Article  CAS  Google Scholar 

  • H.-J. Jin, J. Park, V. Karageorgiou, U.-J. Kim, R. Valluzzi, P. Cebe, D.L. Kaplan, Adv. Func. Mater. 15, 1241 (2005)

    Article  CAS  Google Scholar 

  • N. Johari, L. Moroni, A. Samadikuchaksaraei, Eur. Polymer J. 134, 109842 (2020)

    Article  CAS  Google Scholar 

  • S. Kim, M.S. Lee, H.S. Yang, J.H. Jung, Sci. Rep. 11, 1 (2021)

    Article  ADS  Google Scholar 

  • D.M. Kirchmajer, C.A. Watson, M. Ranson, RSC Adv. 3, 1073 (2013)

    Article  ADS  CAS  Google Scholar 

  • P. Kord Forooshani, B.P. Lee, J. Polym. Sci. Part A: Polym. Chem. 55, 9 (2017)

    Article  ADS  CAS  Google Scholar 

  • R.D. Koyani, Biomanufacturing Reviews 4, 1 (2019)

    Article  Google Scholar 

  • A. Kumar, H. Mohanram, K.W. Kong, R. Goh, S. Hoon, J. Lescar, A. Miserez, Biomaterials Science 6, 2440 (2018)

    Article  CAS  PubMed  Google Scholar 

  • J. Lee, E.H. Jang, J.H. Kim, S. Park, Y. Kang, S. Park, K. Lee, J.-H. Kim, Y.-N. Youn, W. Ryu, J. Control. Release 340, 125 (2021)

    Article  CAS  PubMed  Google Scholar 

  • J. Lee, S.H. Park, I.H. Seo, K.J. Lee, W. Ryu, Eur. J. Pharm. Biopharm. 94, 11 (2015)

    Article  CAS  PubMed  Google Scholar 

  • J.W. Lee, M.-R. Han, J.-H. Park, J. Drug Target. 21, 211 (2013)

    Article  CAS  PubMed  Google Scholar 

  • K. Lee, M.J. Goudie, P. Tebon, W. Sun, Z. Luo, J. Lee, S. Zhang, K. Fetah, H.-J. Kim, Y. Xue, M.A. Darabi, S. Ahadian, E. Sarikhani, W. Ryu, Z. Gu, P.S. Weiss, M.R. Dokmeci, N. Ashammakhi, A. Khademhosseini, Adv. Drug Deliv. Rev. 165–166, 41 (2020a)

    Article  PubMed  Google Scholar 

  • K. Lee, J. Lee, S.G. Lee, S. Park, D.S. Yang, J.-J. Lee, A. Khademhosseini, J.S. Kim, W. Ryu, J. Control. Release 321, 174 (2020b)

    Article  CAS  PubMed  Google Scholar 

  • Y. Lee, S. Park, S.I. Kim, K. Lee, W. Ryu, Advanced Materials Technologies 5, 1901145 (2020c)

    Article  CAS  Google Scholar 

  • D. Li, D. Hu, H. Xu, H.K. Patra, X. Liu, Z. Zhou, J. Tang, N. Slater, Y. Shen, Biomaterials 264, 120410 (2021)

    Article  CAS  PubMed  Google Scholar 

  • S. Lim, T.Y. Park, E.Y. Jeon, K.I. Joo, H.J. Cha, Biomaterials 278, 121171 (2021)

    Article  CAS  PubMed  Google Scholar 

  • Y.-S. Lim, Y.-J. Ok, S.-Y. Hwang, J.-Y. Kwak, S. Yoon, Mar. Drugs 17, 467 (2019)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Z. Lin, Y. Li, G. Meng, X. Hu, Z. Zeng, B. Zhao, N. Lin, X.Y. Liu, Biomacromol 22, 5319 (2021)

    Article  CAS  Google Scholar 

  • R. Liu, M. Zhang, C. Jin, J. Biophotonics 10, 870 (2017)

    Article  CAS  PubMed  Google Scholar 

  • X. Lu, Y. Sun, M. Han, D. Chen, A. Wang, K. Sun, Int. J. Pharm. 613, 121433 (2022)

    Article  CAS  PubMed  Google Scholar 

  • Z. Luo, W. Sun, J. Fang, K. Lee, S. Li, Z. Gu, M.R. Dokmeci, A. Khademhosseini, Adv Healthc Mater 8, e1801054 (2019)

    Article  PubMed  Google Scholar 

  • A. Mahanty, Y.F. Abbasi, H. Bera, M. Chakraborty, and M.A. Al Maruf, Biopolymer-Based Nanomaterials in Drug Delivery and Biomedical Applications. 497 (2021)

  • P. Makvandi, A. Maleki, M. Shabani, A.R. Hutton, M. Kirkby, R. Jamaledin, T. Fang, J. He, J. Lee, B. Mazzolai, Matter 5, 390 (2022)

    Article  CAS  Google Scholar 

  • P. Medhi, O. Olatunji, A. Nayak, C.T. Uppuluri, R.T. Olsson, B.N. Nalluri, D.B. Das, AAPS PharmSciTech 18, 1488 (2017)

    Article  CAS  PubMed  Google Scholar 

  • I. Menon, P. Bagwe, K.B. Gomes, L. Bajaj, R. Gala, M.N. Uddin, M.J. D’Souza, S.M. Zughaier, Micromachines 12, 435 (2021)

    Article  PubMed  PubMed Central  Google Scholar 

  • J.A. Mikszta, J.B. Alarcon, J.M. Brittingham, D.E. Sutter, R.J. Pettis, N.G. Harvey, Nat. Med. 8, 415 (2002)

    Article  CAS  PubMed  Google Scholar 

  • T. Moniz, S.A.C. Lima, S. Reis, Carbohyd. Polym. 266, 118098 (2021)

    Article  CAS  Google Scholar 

  • S.M. Mortazavi, H.R. Moghimi, Int. J. Cosmet. Sci. 44, 232 (2022)

    Article  CAS  PubMed  Google Scholar 

  • N. A. Mustafa Kamal, T. M. Tuan Mahmood, I. Ahmad, S. Ramli, JSM. 49, 2269 (2020)

  • R. Nagarkar, M. Singh, H.X. Nguyen, S. Jonnalagadda, Journal of Drug Delivery Science and Technology 59, 101923 (2020)

    Article  CAS  Google Scholar 

  • R. Nakata, A. Tachibana, T. Tanabe, Mater. Sci. Eng. C 41, 59 (2014)

    Article  CAS  Google Scholar 

  • R. Narayanaswamy, S. Kanagesan, A. Pandurangan, and P. Padmanabhan, Nanobiomater. Med. Imaging. 101 (2016)

  • J. Navarro, J. Swayambunathan, M. Lerman, M. Santoro, J.P. Fisher, Acta Biomater. 83, 177 (2019)

    Article  CAS  PubMed  Google Scholar 

  • K.K. Nayak, P. Gupta, Int. J. Biol. Macromol. 81, 1 (2015)

    Article  CAS  PubMed  Google Scholar 

  • A.W. Newman, I.M. Vitez, R.L. Mueller, C.C. Kiesnowski, W.P. Findlay, C. Rodriguez, M. Davidovich, and G. McGeorge, Analytical Profiles of Drug Substances and Excipients. 452 (1999)

  • Y.-J. Oh, H.-R. Cha, S.J. Hwang, D.-S. Kim, Y.-J. Choi, Y.-S. Kim, Y.-R. Shin, T.T. Nguyen, S.-O. Choi, J.M. Lee, Drug Deliv. Transl. Res. 11, 1390 (2021)

    Article  CAS  PubMed  Google Scholar 

  • O. Olatunji, A. Denloye, J. Polym. Environ. 27, 1252 (2019)

    Article  CAS  Google Scholar 

  • O. Olatunji, C.C. Igwe, A.S. Ahmed, D.O. Alhassan, G.O. Asieba, B.D. Diganta, J. Appl. Polym. Sci. 131, (2014)

  • O. Olatunji, R.T. Olsson, Pharmaceutics 7, 363 (2015)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • O. Olatunji, M. Olubowale, C. Okereke, Polym. Bull. 75, 4103 (2018)

    Article  CAS  Google Scholar 

  • M.P. Olivieri, R.E. Baier, R.E. Loomis, Biomaterials 13, 1000 (1992)

    Article  CAS  PubMed  Google Scholar 

  • N.V. Padaki, B. Das, A. Basu, Advances in silk science and technology. 3 (2015)

    Chapter  Google Scholar 

  • M. N. Padamwar and A. P. Pawar, (2004)

  • W.H. Park, J. Lee, H.J. Kim, K.I. Joo, H.J. Cha, Chem. Eng. J. 137272 (2022)

  • M. Pazhang, F. Mehrnejad, Y. Pazhang, H. Falahati, N. Chaparzadeh, Biotechnol. Appl. Biochem. 63, 206 (2016)

    Article  CAS  PubMed  Google Scholar 

  • S. Petros, T. Tesfaye, M. Ayele, J. Eng. 2020, 1 (2020)

    Article  Google Scholar 

  • R.A. Pineda-Álvarez, M.J. Bernad-Bernad, I.M. Rodríguez-Cruz, J.J. Escobar-Chávez, J. Pharm. Innov. 1, (2020)

  • M.L.P. Pistor, Device for Cutaneous Therapeutic Treatment (Google Patents) (1975)

  • Z. Qi, J. Cao, X. Tao, X. Wu, S.C. Kundu, S. Lu, Pharmaceutics 13, 2198 (2021)

    Article  PubMed  PubMed Central  Google Scholar 

  • F. Raza, L. Siyu, H. Zafar, Z. Kamal, B. Zheng, J. Su, M. Qiu, Curr. Pharm. Des. 28, 380 (2022)

    Article  CAS  PubMed  Google Scholar 

  • S. Ruan, Y. Zhang, N. Feng, Biomater. Sci. 9, 8065 (2021)

    Article  CAS  PubMed  Google Scholar 

  • A.H. Sabri, J. Ogilvie, K. Abdulhamid, V. Shpadaruk, J. McKenna, J. Segal, D.J. Scurr, M. Marlow, Eur. J. Pharm. Biopharm. 140, 121 (2019)

    Article  PubMed  Google Scholar 

  • M. Santoro, A.M. Tatara, A.G. Mikos, J. Control. Release 190, 210 (2014)

    Article  CAS  PubMed  Google Scholar 

  • J.M. Saul, M.D. Ellenburg, R.C. De Guzman, M.V. Dyke, J. Biomed. Mater. Res., Part A 98, 544 (2011)

    Article  Google Scholar 

  • J. Schnurrer, C.-M. Lehr, Int. J. Pharm. 141, 251 (1996)

    Article  CAS  Google Scholar 

  • C.E. Brubaker, P.B. Messersmith, S.N. Aqida Syed Ahmad, Polym. Sci. 9, 211–229 (2012)

    CAS  Google Scholar 

  • A.A. Seetharam, H. Choudhry, M.A. Bakhrebah, W.H. Abdulaal, M.S. Gupta, S.M.D. Rizvi, Q. Alam, Siddaramaiah, D.V. Gowda, A. Moin, Pharmaceutics 12, 1101 (2020)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • F.P. Seib, G.T. Jones, J. Rnjak-Kovacina, Y. Lin, D.L. Kaplan, Adv. Healthcare Mater. 2, 1606 (2013)

    Article  CAS  Google Scholar 

  • D. Shin, J. Hyun, J. Ind. Eng. Chem. 95, 126 (2021)

    Article  CAS  Google Scholar 

  • H.G. Silverman, F.F. Roberto, Mar. Biotechnol. 9, 661 (2007)

    Article  CAS  Google Scholar 

  • J.A. Stinson, A.V. Boopathy, B.M. Cieslewicz, Y. Zhang, N.W. Hartman, D.P. Miller, M. Dirckx, B.L. Hurst, E.B. Tarbet, J.A. Kluge, K.M. Kosuda, Vaccine 39, 5410 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • J.A. Stinson, W.K. Raja, S. Lee, H.B. Kim, I. Diwan, S. Tutunjian, B. Panilaitis, F.G. Omenetto, S. Tzipori, D.L. Kaplan, ACS Biomater. Sci. Eng. 3, 360 (2017)

    Article  CAS  PubMed  Google Scholar 

  • M. Sugimoto, K. Matsubara, Y. Koida, M. Kobayashi, Pharm. Dev. Technol. 6, 487 (2001)

    Article  CAS  PubMed  Google Scholar 

  • Y. Tanaka, J. Clin. Aesthet. Dermatol. 10, 45 (2017)

    PubMed  PubMed Central  Google Scholar 

  • J. Tang, J. Wang, K. Huang, Y. Ye, T. Su, L. Qiao, M.T. Hensley, T.G. Caranasos, J. Zhang, Z. Gu, Sci. Adv. 4, eaat9365 (2018)

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  • S. Tomblyn, E.L. Pettit Kneller, S.J. Walker, M.D. Ellenburg, C.J. Kowalczewski, M. Van Dyke, L. Burnett, J.M. Saul, J. Biomed. Mater. Res. B Appl. Biomater. 104, 864 (2016)

    Article  CAS  PubMed  Google Scholar 

  • G. Traverso, C.M. Schoellhammer, A. Schroeder, R. Maa, G.Y. Lauwers, B.E. Polat, D.G. Anderson, D. Blankschtein, R. Langer, J. Pharm. Sci. 104, 362 (2015)

    Article  CAS  PubMed  Google Scholar 

  • K. Tsioris, W.K. Raja, E.M. Pritchard, B. Panilaitis, D.L. Kaplan, F.G. Omenetto, Adv. Func. Mater. 22, 330 (2012)

    Article  CAS  Google Scholar 

  • J.E. Ulloa Rojas, V.L. de Oliveira, D.R. de Araujo, G.R. Tofoli, M.M. de Oliveira, D.J. Carastan, M. Palaci, F. Giuntini, W.A. Alves, ACS Biomater. Sci. Eng. 8, 128 (2022)

    Article  CAS  PubMed  Google Scholar 

  • V. Verma, P. Verma, P. Ray, A.R. Ray, Biomed. Mater. 3, 025007 (2008)

    Article  ADS  PubMed  Google Scholar 

  • L.K. Vora, K. Moffatt, I.A. Tekko, A.J. Paredes, F. Volpe-Zanutto, D. Mishra, K. Peng, R. Raj Singh Thakur, and R. F. Donnelly, Eur. J. Pharm. Biopharm. 159, 44 (2021)

    Article  CAS  PubMed  Google Scholar 

  • N. Wang, Y. Zhen, Y. Jin, X. Wang, N. Li, S. Jiang, T. Wang, J. Control. Release 246, 12 (2017)

    Article  CAS  PubMed  Google Scholar 

  • S. Wang, M. Zhu, L. Zhao, D. Kuang, S.C. Kundu, S. Lu, ACS Biomater. Sci. Eng. 5, 1887 (2019)

    Article  CAS  PubMed  Google Scholar 

  • Z. Wang, Z. Yang, J. Jiang, Z. Shi, Y. Mao, N. Qin, T.H. Tao, Adv. Mater. 34, e2106606 (2022)

    Article  PubMed  Google Scholar 

  • L. Xiao, G. Lu, Q. Lu, D.L. Kaplan, ACS Biomater. Sci. Eng. 2, 2050 (2016)

    Article  CAS  PubMed  Google Scholar 

  • S. Xu, L. Sang, Y. Zhang, X. Wang, X. Li, Mater. Sci. Eng. C 33, 648 (2013)

    Article  CAS  Google Scholar 

  • J. Y, J. Yk, K. Bj, Y. B, J. Ki, C. Hj, ACS Nano. 12, 8909 (2018)

  • L. Yan, M. Alba, N. Tabassum, N.H. Voelcker, Adv. Ther. 2, 1900141 (2019)

    Article  CAS  Google Scholar 

  • G. Yang, Q. Chen, D. Wen, Z. Chen, J. Wang, G. Chen, Z. Wang, X. Zhang, Y. Zhang, Q. Hu, ACS Nano 13, 4354 (2019)

    Article  CAS  PubMed  Google Scholar 

  • J. Yang, J. Yang, X. Gong, Y. Zheng, S. Yi, Y. Cheng, Y. Li, B. Liu, X. Xie, C. Yi, Adv. Healthc. Mater. 11, 2102547 (2022)

    Article  CAS  Google Scholar 

  • Y.W. Yew, C.Z.Y. Phuan, X. Zhao, E.S.T. Tan, W.S. Chong, H.L. Tey, Annals of the Academy of Medicine. Singapore 51, 16 (2022)

    Google Scholar 

  • M. Yin, J. Wu, M. Deng, P. Wang, G. Ji, M. Wang, C. Zhou, N.T. Blum, W. Zhang, H. Shi, ACS Nano 15, 17842 (2021)

    Article  CAS  PubMed  Google Scholar 

  • Z. Yin, D. Kuang, S. Wang, Z. Zheng, V.K. Yadavalli, S. Lu, Int. J. Biol. Macromol. 106, 48 (2018)

    Article  CAS  PubMed  Google Scholar 

  • X. You, J. Chang, B.-K. Ju, J.J. Pak, Mater. Sci. Eng. C 31, 1632 (2011)

    Article  CAS  Google Scholar 

  • W. Yu, G. Jiang, D. Liu, L. Li, H. Chen, Y. Liu, Q. Huang, Z. Tong, J. Yao, X. Kong, Mater Sci Eng C Mater Biol Appl 71, 725 (2017a)

    Article  CAS  PubMed  Google Scholar 

  • W. Yu, G. Jiang, D. Liu, L. Li, Z. Tong, J. Yao, X. Kong, Mater Sci Eng C Mater Biol Appl 73, 425 (2017b)

    Article  CAS  PubMed  Google Scholar 

  • W. Yuan, D. Chen, R. Sarabia-Estrada, H. Guerrero-Cázares, D. Li, A. Quiñones-Hinojosa, X. Li, Sci. Adv. 6, eaaz9664 (2020)

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  • Z. Zeng, G. Jiang, T. Liu, G. Song, Y. Sun, X. Zhang, Y. Jing, M. Feng, Y. Shi, Bio-Des. Manuf. 4, 902 (2021)

    Article  CAS  Google Scholar 

  • J. Zhan, P. Lan, J. Res. Updates Polym. Sci. 1, 59 (2012)

    Article  CAS  Google Scholar 

  • D. Zhang, D.B. Das, C.D. Rielly, Drug Deliv. 21, 571 (2014)

    Article  CAS  PubMed  Google Scholar 

  • X. Zhang, M.M. Hasani-Sadrabadi, J. Zarubova, E. Dashtimighadam, R. Haghniaz, A. Khademhosseini, M.J. Butte, A. Moshaverinia, T. Aghaloo, S. Li, Matter 5, 666 (2022)

    Article  CAS  PubMed  Google Scholar 

  • X. Zhang, Y. Wang, J. Chi, Y. Zhao, Research 2020, 7462915(2020)

  • L. Zhao, Z. Wen, F. Jiang, Z. Zheng, S. Lu, RSC Adv. 10, 6163 (2020)

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  • X. Zhou, Z. Luo, A. Baidya, H.-J. Kim, C. Wang, X. Jiang, M. Qu, J. Zhu, L. Ren, F. Vajhadin, P. Tebon, N. Zhang, Y. Xue, Y. Feng, C. Xue, Y. Chen, K. Lee, J. Lee, S. Zhang, C. Xu, N. Ashammakhi, S. Ahadian, M.R. Dokmeci, Z. Gu, W. Sun, A. Khademhosseini, Adv. Healthc. Mater. 9, (2020)

  • J. Zhu, X. Zhou, H.-J. Kim, M. Qu, X. Jiang, K. Lee, L. Ren, Q. Wu, C. Wang, X. Zhu, P. Tebon, S. Zhang, J. Lee, N. Ashammakhi, S. Ahadian, M.R. Dokmeci, Z. Gu, W. Sun, A. Khademhosseini, Small 16, e1905910 (2020a)

  • M. Zhu, Y. Liu, F. Jiang, J. Cao, S.C. Kundu, S. Lu, A.C.S. Biomater, Sci. Eng. 6, 3422 (2020b)

    CAS  Google Scholar 

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Funding

We appreciate the support from the Shahid Beheshti University of Medical Sciences (No.43003930).

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Authors and Affiliations

  1. Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Maedeh Barati, Shiva Hashemi, Mahsa Sayed Tabatabaei, Nasrin Zarei Chamgordani, Seyedeh Maryam Mortazavi & Hamid Reza Moghimi

  2. Protein Technology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Hamid Reza Moghimi

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  1. Maedeh Barati
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  2. Shiva Hashemi
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  3. Mahsa Sayed Tabatabaei
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  5. Seyedeh Maryam Mortazavi
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Contributions

Literature search: M.B., S.H., M.S.T., and N.Z.C. Data extraction and analysis: M.B., S.H., M.S.T., and N.Z.C. Figures’ design and plotting: M.B., S.H., and M.S.T. Manuscript drafting: M.B., S.H., M.S.T., and N.Z.C. Manuscript revising: S.M.M. and H.R.M. Supervision: H.R.M.

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Correspondence to Hamid Reza Moghimi.

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Barati, M., Hashemi, S., Sayed Tabatabaei, M. et al. Protein-based microneedles for biomedical applications: A systematic review. Biomed Microdevices 26, 19 (2024). https://doi.org/10.1007/s10544-024-00701-6

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