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Synthesis, spectroscopic characterization and in vitro anticancer activity of new platinum(II) complexes with some thione ligands in the presence of triethylphosphine

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A Correction to this article was published on 11 August 2020

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Abstract

Seven new platinum(II) complexes (1–7) of triethylphosphine (Et3P) and thiones (L) with general formula, cis-[Pt(Et3P)2(L)2]Cl2 were prepared and characterized by elemental analysis, FTIR and NMR (1H, 13C & 31P) measurements. The analytical and spectroscopic data suggested the formation of the desired complexes. The complexes were tested for in vitro cytotoxicity against four cell lines: Hela (human cervical adenocarcinoma), MCF-7 (human breast carcinoma), A549 (human lung carcinoma), and HTC15 (human colon carcinoma). The anticancer activity values of compounds 1–6 are much better than cisplatin and carboplatin as indicated by their IC50 values.

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  • 11 August 2020

    Due to an unfortunate turn of events, the main affiliation of Dr. Saleh Altuwaijri was omitted from the above mentioned three articles. The complete affiliations are published below and should be treated as definitive.

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Acknowledgement

This research was supported by the King Fahd University Petroleum and Minerals Research Committee under project No. IN161005.

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Authors and Affiliations

  1. Department of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran, 31261, Saudi Arabia

    Mohammed Yagoub Jomaa & Anvarhusein A. Isab

  2. Center of Research Excellence in Nanotechnology, King Fahd University of Petroleum & Minerals, Dhahran, 31261, Saudi Arabia

    Muhammed Altaf

  3. Department of Chemistry, College of Sciences and Humanities, Prince Sattam bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia

    Saeed Ahmad

  4. Department of Molecular, Biology & Biochemistry, Guru Nanak Dev University, Amritsar, 143005, India

    Gaurav Bhatia & Jatinder Singh

  5. Clinical Research Laboratory, SAAD Research Development Center, SAAD Specialist Hospital, Al-Khobar, 31952, Saudi Arabia

    Saleh Altuwaijri

Authors
  1. Mohammed Yagoub Jomaa
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  2. Muhammed Altaf
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  3. Saeed Ahmad
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  4. Gaurav Bhatia
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  5. Jatinder Singh
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  6. Saleh Altuwaijri
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  7. Anvarhusein A. Isab
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Correspondence to Anvarhusein A. Isab.

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Jomaa, M.Y., Altaf, M., Ahmad, S. et al. Synthesis, spectroscopic characterization and in vitro anticancer activity of new platinum(II) complexes with some thione ligands in the presence of triethylphosphine. Biometals 30, 787–795 (2017). https://doi.org/10.1007/s10534-017-0047-5

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  • DOI: https://doi.org/10.1007/s10534-017-0047-5

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