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Investigating the biological degradation of the drug β-blocker atenolol from wastewater using the SBR

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A Correction to this article was published on 11 September 2023

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Abstract

Drug compounds are one of the main contributors to the entry of micro-pollutants into the environment, known as a constant threat to environmental stability. Atenolol is a type of beta-blocker extensively used to cure cardiovascular disorders. The residues of this compound have been continuously detected in aquatic environments because it is a polar and poorly biodegradable compound. Thus, removing atenolol from wastewater is essential before discharging into the environment. Biological processes are considered the most important removal process for polar drugs in wastewater treatment plants. Accordingly, for the first time in this study, the SBR performance was investigated in the biodegradation and mineralization of atenolol under different concentrations (50–600 mg/L) and hydraulic retention times (48–32 h). Based on the results, the time required for the acclimation of biomass to atenolol (C: 50 mg/L and the HRT: 48 h) was 80 days. The SBR efficiencies under optimum conditions (C: 400 mg/L and HRT: 40 h) in removing the atenolol and COD were 91% and 87%, respectively. For the first time in this study, one of the main pathways of the atenolol biodegradation was identified. Based on the review and comparison of the results of this study with existing literature showing that the SBR used in this study was able to remove higher concentrations with better efficiencies than other processes. Therefore, it can be concluded that the SBR used in this study could be considered an efficient and promising technique for treating wastewaters containing atenolol and other beta-blocker group drugs.

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References

  • Aghapour AA, Moussavi G, Yaghmaeian K (2013a) Biological degradation of catechol in wastewater using the sequencing continuous-inflow reactor (SCR). J Environ Health Sci Eng 11(1):3

    Article  PubMed  PubMed Central  Google Scholar 

  • Aghapour AA, Moussavi G, Yaghmaeian K (2013b) Investigating the performance of a novel cyclic rotating-bed biological reactor compared with a sequencing continuous-inflow reactor for biodegradation of catechol in wastewater. Bioresour Technol 138:369–372

    Article  CAS  PubMed  Google Scholar 

  • Ahmed MB et al (2017) Progress in the biological and chemical treatment technologies for emerging contaminant removal from wastewater: a critical review. J Hazard Mater 323:274–298

    Article  CAS  PubMed  Google Scholar 

  • Almeida J et al (1995) Nitrite inhibition of denitrification by Pseudomonas fluorescens. Biotechnol Bioeng 46(3):194–201

    Article  CAS  PubMed  Google Scholar 

  • Arya V, Philip L, Bhallamudi SM (2016) Performance of suspended and attached growth bioreactors for the removal of cationic and anionic pharmaceuticals. Chem Eng J 284:1295–1307

    Article  CAS  Google Scholar 

  • Ashraf SA et al (2017) In-vitro antimicrobial activity and identification of bioactive components using GC-MS of commercially available essential oils in Saudi Arabia. J Food Sci Technol 54(12):3948–3958

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dehdashti B et al (2019) Atenolol adsorption onto multi-walled carbon nanotubes modified by NaOCl and ultrasonic treatment; kinetic, isotherm, thermodynamic, and artificial neural network modeling. J Environ Health Sci Eng 17(1):281–293

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fenner K et al (2008) Data-driven extraction of relative reasoning rules to limit combinatorial explosion in biodegradation pathway prediction. Bioinformatics 24(18):2079–2085

    Article  CAS  PubMed  Google Scholar 

  • Foglar L et al (2005) High nitrate removal from synthetic wastewater with the mixed bacterial culture. Bioresour Technol 96(8):879–888

    Article  CAS  PubMed  Google Scholar 

  • Golan-Rozen N, Seiwert B, Riemenschneider C, Reemtsma T, Chefetz B, Hadar Y (2015) Transformation pathways of the recalcitrant pharmaceutical compound carbamazepine by the white-rot fungus Pleurotus ostreatus: effects of growth conditions. Environ Sci Technol 49(20):12351–12362

    Article  Google Scholar 

  • Hai R et al (2015) Simultaneous removal of nitrogen and phosphorus from swine wastewater in a sequencing batch biofilm reactor. Chin J Chem Eng 23(1):303–308

    Article  CAS  Google Scholar 

  • Hinojosa-Reyes M et al (2017) H2Ti3O7 nanotubes decorated with silver nanoparticles for photocatalytic degradation of atenolol. J Nanomaterials. https://doi.org/10.1155/2017/9610419

    Article  Google Scholar 

  • Isarain-Chávez E et al (2010) Mineralization of the drug β-blocker atenolol by electro-Fenton and photoelectro-Fenton using an air-diffusion cathode for H2O2 electrogeneration combined with a carbon-felt cathode for Fe2 + regeneration. Appl Catal B 96(3):361–369

    Article  Google Scholar 

  • Jafari SJ, Moussavi G, Yaghmaeian K (2015) High-rate biological denitrification in the cyclic rotating-bed biological reactor: effect of COD/NO3-, nitrate concentration and salinity and the phylogenetic analysis of denitrifiers. Bioresour Technol 197:482–488

    Article  CAS  PubMed  Google Scholar 

  • Ji Y et al (2012) Nitrate-induced photodegradation of atenolol in aqueous solution: kinetics, toxicity and degradation pathways. Chemosphere 88(5):644–649

    Article  CAS  PubMed  Google Scholar 

  • Ji Y et al (2013) Photocatalytic degradation of atenolol in aqueous titanium dioxide suspensions: kinetics, intermediates and degradation pathways. J Photochem Photobiol A 254:35–44

    Article  CAS  Google Scholar 

  • Kanaujiya DK et al (2019) Biological treatment processes for the removal of organic micropollutants from wastewater: a review. Curr Pollut Rep 5(3):112–128

    Article  Google Scholar 

  • Khorsandi H, Ghochlavi N, Aghapour AA (2018) Biological degradation of 2, 4, 6-trichlorophenol by a sequencing batch reactor. Environ Processes 5(4):907–917

    Article  CAS  Google Scholar 

  • Khorsandi H, Gholizadeh M, Aghapour Aa (2020) Catechol biodegradation by a novel hybrid anoxic biofilter. Environ Technol 41(6):777–784

    Article  CAS  PubMed  Google Scholar 

  • Kyzas GZ et al (2015) Removal of beta-blockers from aqueous media by adsorption onto graphene oxide. Sci Total Environ 537:411–420

    Article  CAS  PubMed  Google Scholar 

  • Lapworth D et al (2012) Emerging organic contaminants in groundwater: a review of sources, fate and occurrence. Environ Pollut 163:287–303

    Article  CAS  PubMed  Google Scholar 

  • Liu J-L, Wong M-H (2013) Pharmaceuticals and personal care products (PPCPs): a review on environmental contamination in China. Environ Int 59:208–224

    Article  CAS  PubMed  Google Scholar 

  • Liu X et al (2013) Degradation of atenolol by UV/peroxymonosulfate: kinetics, effect of operational parameters and mechanism. Chemosphere 93(11):2717–2724

    Article  CAS  PubMed  Google Scholar 

  • Mohan SV et al (2005) Treatment of complex chemical wastewater in a sequencing batch reactor (SBR) with an aerobic suspended growth configuration. Process Biochem 40(5):1501–1508

    Article  CAS  Google Scholar 

  • Moussavi G, Heidarizad M (2010) Biodegradation of mixture of phenol and formaldehyde in wastewater using a single-basin MSCR process. J Biotechnol 150(2):240–245

    Article  CAS  PubMed  Google Scholar 

  • Moussavi G, Heidarizad M (2011) The performance of SBR, SCR, and MSCR for simultaneous biodegradation of high concentrations of formaldehyde and ammonia. Sep Purif Technol 77(2):187–195

    Article  CAS  Google Scholar 

  • Moussavi G, Jafari SJ, Yaghmaeian K (2015) Enhanced biological denitrification in the cyclic rotating bed reactor with catechol as carbon source. Bioresour Technol 189:266–272

    Article  CAS  PubMed  Google Scholar 

  • Najafpour G, Zinatizadeh A, Lee L (2006) Performance of a three-stage aerobic RBC reactor in food canning wastewater treatment. Biochem Eng J 30(3):297–302

    Article  CAS  Google Scholar 

  • Peng L et al (2015) Biodegradation of pharmaceuticals in membrane aerated biofilm reactor for autotrophic nitrogen removal: a model-based evaluation. J Membr Sci 494:39–47

    Article  CAS  Google Scholar 

  • Quaresma AV et al (2019) Oxidative treatments for atenolol removal in water: Elucidation by mass spectrometry and toxicity evaluation of degradation products. Rapid Commun Mass Spectrom 33(3):303–313

    Article  CAS  PubMed  Google Scholar 

  • Radjenović J et al (2008) Identification and structural characterization of biodegradation products of atenolol and glibenclamide by liquid chromatography coupled to hybrid quadrupole time-of-flight and quadrupole ion trap mass spectrometry. J Chromatogr A 1210(2):142–153

    Article  PubMed  Google Scholar 

  • Rastogi T, Leder C, Kümmerer K (2015) A sustainable chemistry solution to the presence of pharmaceuticals and chemicals in the aquatic environment–the example of re-designing β-blocker Atenolol. RSC Adv 5(1):27–32

    Article  CAS  Google Scholar 

  • Richardson SD, Kimura SY (2017) Emerging environmental contaminants: challenges facing our next generation and potential engineering solutions. Environ Technol Innov 8:40–56

    Article  Google Scholar 

  • Shen Z et al (2013) Denitrification performance and microbial diversity in a packed-bed bioreactor using biodegradable polymer as carbon source and biofilm support. J Hazard Mater 250:431–438

    Article  PubMed  Google Scholar 

  • Sirianuntapiboon S, Jeeyachok N, Larplai R (2005) Sequencing batch reactor biofilm system for treatment of milk industry wastewater. J Environ Manag 76(2):177–183

    Article  CAS  Google Scholar 

  • Stadler LB et al (2015) Effect of redox conditions on pharmaceutical loss during biological wastewater treatment using sequencing batch reactors. J Hazard Mater 282:106–115

    Article  CAS  PubMed  Google Scholar 

  • Tammaro M et al (2017) Photocatalytic degradation of atenolol in aqueous suspension of new recyclable catalysts based on titanium dioxide. J Environ Chem Eng 5(4):3224–3234

    Article  CAS  Google Scholar 

  • Tchobanoglous G, Burton FL, Stensel HD (2003) Metcalf & Eddy wastewater engineering: treatment and reuse, Vol. 4. McGrawHill, New York, pp 361–411

    Google Scholar 

  • To M-H et al (2017) Mechanistic study of atenolol, acebutolol and carbamazepine adsorption on waste biomass derived activated carbon. J Mol Liq 241:386–398

    Article  CAS  Google Scholar 

  • Valcárcel Y et al (2011) Analysis of the presence of cardiovascular and analgesic/anti-inflammatory/antipyretic pharmaceuticals in river-and drinking-water of the Madrid Region in Spain. Chemosphere 82(7):1062–1071

    Article  PubMed  Google Scholar 

  • Wang Y-F et al (2014) Treatment of high salinity phenol-laden wastewater using a sequencing batch reactor containing halophilic bacterial community. Int Biodeterior Biodegrad 93:138–144

    Article  CAS  Google Scholar 

  • Water Environmental Federation, and American Public Health Association (APHA) (2005) Standard methods for the examination of water and wastewater. American Public Health Association (APHA): Washington, DC, USA 21

  • Wei C-H et al (2018) Organic micropollutants removal in sequential batch reactor followed by nanofiltration from municipal wastewater treatment. Bioresour Technol 268:648–657

    Article  CAS  PubMed  Google Scholar 

  • Xu Y et al (2017a) Biodegradation of atenolol by an enriched nitrifying sludge: Products and pathways. Chem Eng J 312:351–359

    Article  CAS  Google Scholar 

  • Xu Y, Yuan Z, Ni B-J (2017b) Impact of Ammonium Availability on Atenolol Biotransformation during Nitrification. ACS Sustain Chem Eng 5(8):7137–7144

    Article  CAS  Google Scholar 

  • Yi M et al (2022) Novel pathway and acetate-facilitated complete atenolol degradation by Hydrogenophaga sp. YM1 isolated from activated sludge. Sci Total Environ 810:152218

    Article  CAS  PubMed  Google Scholar 

  • Zeng C et al (2012) The role of dissolved organic matters in the aquatic photodegradation of atenolol. J Hazard Mater 239:340–347

    Article  PubMed  Google Scholar 

  • Zhang S et al (2021) Indicator compounds representative of contaminants of emerging concern (CECs) found in the water cycle in the United States. Int J Environ Res Public 18(3):1288

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Environmental Health Engineering Department, School of Public Health, Urmia University of Medical Sciences, Urmia, Iran

    Reza Rezaei & Ali Ahmad Aghapour

  2. Environmental Health Engineering Department, School of Public Health, Urmia University of Medical Sciences, Urmia, Iran

    Hassan Khorsandi

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  1. Reza Rezaei
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  2. Ali Ahmad Aghapour
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  3. Hassan Khorsandi
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Correspondence to Ali Ahmad Aghapour.

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Rezaei, R., Aghapour, A.A. & Khorsandi, H. Investigating the biological degradation of the drug β-blocker atenolol from wastewater using the SBR. Biodegradation 33, 267–281 (2022). https://doi.org/10.1007/s10532-022-09979-w

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