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RETRACTED ARTICLE: miR-599 inhibits proliferation and invasion of glioma by targeting periostin

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This article was retracted on 12 September 2023

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Abstract

Objective

To explore the molecular mechanism of microRNA-599(miR-599) in the migration and invasion of glioma.

Result

Clinicopathological characteristics of 33 patients were analyzed. Based on reverse transcription-PCR, miR-599 was down-regulated in glioma tissues compared with adjacent normal brain tissues (P < 0.001). Moreover, negative correlations between miR-599 and periostin protein expression in glioma tissues (P < 0.01) and necrosis by magnetic resonance imaging (P < 0.05) were observed. Transwell and wound healing assays showed that overexpression of miR-599 inhibited glioma cell migration and invasion. miR-599 down-regulated periostin expression by targeting the 3′-untranslated region. Additionally, re-expression of periostin partial reversed the suppressive effect of miR-599 on migration and invasion in vitro and in vivo.

Conclusion

microRNA-599 inhibits proliferation and invasion by down-regulating periostin expression in vitro and in vivo.

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Supplementary information

Supplementary Table 1—Primer sequences used.

Author information

Author notes

  1. Tingting Zhang and Guangtao Ma have been contributed equally to this work.

Authors and Affiliations

  1. School of Basic Medical Science; School of Information Science and Engineering, Central South University, Changsha, Hunan Province, 410078, China

    Tingting Zhang

  2. Department of Neurosurgery, Daqing Oil Field General Hospital, Daqing, Heilongjiang Province, 163000, China

    Guangtao Ma

  3. Department of The Heart of Non-invasive Examination, Daqing Oil Field General Hospital, Daqing, Heilongjiang Province, 163000, China

    Yan Zhang

  4. Daqing Convalescence Hospital, Daqing, Heilongjiang Province, 163000, China

    Hongda Huo

  5. School of Information Science and Engineering, Central South University, Tongzipo Road No.172, Changsha, Hunan Province, 410078, China

    Yuqian Zhao

Authors
  1. Tingting Zhang
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  2. Guangtao Ma
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  3. Yan Zhang
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  4. Hongda Huo
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Corresponding author

Correspondence to Yuqian Zhao.

Electronic supplementary material

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Supplementary material 1 (DOCX 13 kb)

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Zhang, T., Ma, G., Zhang, Y. et al. RETRACTED ARTICLE: miR-599 inhibits proliferation and invasion of glioma by targeting periostin. Biotechnol Lett 39, 1325–1333 (2017). https://doi.org/10.1007/s10529-017-2365-7

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  • DOI: https://doi.org/10.1007/s10529-017-2365-7

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