Abstract
Bone formation induced by phosphoserine was investigated in vitro and in vivo using MC3T3-E1 cells and a rabbit calvarial osseous defect model. MC3T3-E1 cells supplemented by phosphoserine displayed two-fold higher alkaline phosphatase activity and mineralization nodule formation, and calvarial defects treated with phosphoserine showed statistically significant new bone formation compared with the control (P < 0.05).
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Acknowledgment
This study was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (A090350).
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Park, JW., Kim, YJ., Jang, JH. et al. MC3T3-E1 cell differentiation and in vivo bone formation induced by phosphoserine. Biotechnol Lett 33, 1473–1480 (2011). https://doi.org/10.1007/s10529-011-0565-0
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DOI: https://doi.org/10.1007/s10529-011-0565-0