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Interaction Between Hypoxia-Inducible Factor 1-alpha Gene Polymorphism and Helicobacter pylori Infection on Gastric Cancer in a Chinese Tibetan Population

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Abstract

To investigate the impact of four single nucleotide polymorphisms (SNPs) of the HIF1α gene and its interaction with Helicobacter pylori (H. pylori) infection on susceptibility to gastric cancer (GC).

Logistic regression was used to test the relationship between four SNPs of HIF1α gene and the susceptibility of GC. A generalized multifactor dimensionality reduction (GMDR) model was used to assess the HIF1α gene-H. pylori infection interaction.

Logistic regression analysis indicated that both the rs11549465-CT genotype and the T allele were associated with an increased risk of GC, adjusted OR (95% CI) were 1.63 (1.09–2.20) (CT vs. CC) and 1.70 (1.13–2.36) (T vs. C), respectively. We also found that both the rs11549467-A allele and rs11549467-GA genotype were associated with an increased risk of GC, and adjusted OR (95% CI) were 2.21 (1.61–2.86) (GA vs. GG), 2.13 (1.65–2.65) (A vs. G), respectively. However, no statistically significant impact of rs2057482 or rs1957757 on risk of GC was found. The GMDR model indicated a statistically significant two-dimensional model combination (including rs11549467 and H. pylori infection). The selected model had testing balanced accuracy of 0.60 and the best cross-validation consistencies of 10/10 (p = 0.0107). Compared with H. pylori infection negative participants with rs11549467-GG genotype, H. pylori positive participants with the rs11549467-GA genotype had the highest GC risk, the OR (95% CI) was 3.04 (1.98–4.12).

The rs11549467-A allele and rs11549467-GA genotype was associated with increased GC risk. Additionally, the gene-environment interaction between HIF-1α-rs11549467 and H. pylori infection was also correlated with an increased risk of GC.

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Data Availability

Not applicable.

Abbreviations

GC:

Gastric cancer

HIF-1:

Hypoxia-inducible factor 1

SNP:

Single nucleotide polymorphisms

HWE:

Hardy–Weinberg equilibrium

H. pylori :

Helicobacter pylori

GMDR:

Generalized multifactor dimensionality reduction

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Acknowledgements

We appreciate the cooperation of the partners and staffs cooperated in this study.

Funding

Natural Science Foundation of Qinghai Province (No: 2022-ZJ-969Q); The Qinghai Province “Talent in kunlun·High-end innovative and entrepreneurial talents” Programme (No: 2020-18).

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Authors and Affiliations

  1. Department of Gastroenterology, The Affiliated Hospital of Qinghai University, 29 Tongren Road, Xining, 810001, Qinghai, China

    Su-Hua Li, Yan Li, Meng-Jun Zhang, Qi An, Jia-Nan Tao & Xue-Hong Wang

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  1. Su-Hua Li
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  2. Yan Li
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  4. Qi An
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Contributions

All authors have read and approved the manuscript. Su-Hua Li: manuscript writing, editing and review. Yan Li and Meng-Jun Zhang: statistical analysis. Qi An and Jia-Nan Tao: literature research, data acquisition. Xue-Hong Wang: data verification.

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Correspondence to Su-Hua Li.

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Each participant understood the process of the study and signed a written informed consent before the start of the study.

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All study protocols of the current study were approved by ethics committee of Shanxi Province Cancer Hospital. All methods were performed in accordance with the Declaration of Helsinki.

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Li, SH., Li, Y., Zhang, MJ. et al. Interaction Between Hypoxia-Inducible Factor 1-alpha Gene Polymorphism and Helicobacter pylori Infection on Gastric Cancer in a Chinese Tibetan Population. Biochem Genet (2024). https://doi.org/10.1007/s10528-024-10776-8

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