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Association of the Hypoxia Inducible Factor-1α Gene Polymorphisms with Gastric Cancer in Tibetans

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Abstract

To determine how single nucleotide polymorphisms (SNPs) in the hypoxia inducible factor-1α (HIF-1α) gene coding regions affect gastric cancer, the authors conducted an association study of the HIF-1α polymorphisms C1772T and G1790A for a Tibet population. DNA was extracted from peripheral blood of 87 gastric cancer patients and 106 controls and analyzed using the polymerase chain reaction/ligase detection reaction test for HIF-1α polymorphisms. There was a significant increase in the frequency of the GA 1790 genotype in patients with gastric cancer compared with healthy controls (OR 2.93; 95% CI 1.06–8.06). The genotype frequency of the HIF-1α G1790A allele A is higher in gastric cancer groups than in controls (OR 2.78; 95% CI 1.03–7.45). As for the C1772T polymorphism, no positive correlation was found between gastric cancer patients and controls (P = 0.06). Our results suggest that the HIF-1α G1790A polymorphism may be associated with gastric cancer in Tibetans.

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Acknowledgments

This study is sponsored by the Gastroenterology Department of the Nanfang Hospital, Southern Medical University, and Tibet Institute of Digestive Disease. The authors gratefully thank the staff members of the Tibet Institute of Digestive Disease, including Prof. Zeng Dan, Dr. Zhuoma Ci Ren, and Dr. Cuomu Zha Xi, for their participation in this study. All the genotyping experiments were done by Shanghai BioWing Applied Biotechnology Company (http://www.biowing.com.cn).

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Authors and Affiliations

  1. Gastroenterology Department of Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China

    Kang Li, Yali Zhang, Zeng Dan, Yi Wang & Zhuoma Ci Ren

  2. Tibet Institute of Digestive Disease, Lhasa, 850000, China

    Kang Li, Yali Zhang, Zeng Dan, Yi Wang & Zhuoma Ci Ren

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  1. Kang Li
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  2. Yali Zhang
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  3. Zeng Dan
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  4. Yi Wang
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  5. Zhuoma Ci Ren
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Correspondence to Yali Zhang.

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Li, K., Zhang, Y., Dan, Z. et al. Association of the Hypoxia Inducible Factor-1α Gene Polymorphisms with Gastric Cancer in Tibetans. Biochem Genet 47, 625–634 (2009). https://doi.org/10.1007/s10528-009-9254-2

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  • DOI: https://doi.org/10.1007/s10528-009-9254-2

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