Abstract
With the increasing number of aged population and growing burden of healthy aging demands, a rational standard for evaluation aging is in urgent need. The advancement of medical testing technology and the prospering of artificial intelligence make it possible to evaluate the biological status of aging from a more comprehensive view. In this review, we introduced common aging biomarkers and concluded several famous aging clocks. Aging biomarkers reflect changes in the organism at a molecular or cellular level over time while aging clocks tend to be more of a generalization of the overall state of the organism. We expect to construct a framework for aging evaluation measurement from both micro and macro perspectives. Especially, population-specific aging clocks and multi-omics aging clocks may better fit the demands to evaluate aging in a comprehensive and multidimensional manner and make a detailed classification to represent different aging rates at tissue/organ levels. This framework will promisingly provide a crucial basis for disease diagnosis and intervention assessment in geroscience.
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This work was supported by the Zhejiang Provincial Medical and Health Science and Technology Project (Grant Numbers 2021RC070 and 2022KY825),the Zhejiang Province Public Welfare Technology Research Project (Grant Number LGD21H160002), Natural Scientific Foundation of Zhejiang province ( Grant Number LQ22H160015), "Pioneer" and "Leading Goose" R&D Program of Zhejiang, (Grant Number 2022C03145).
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Wang, Q., Hou, T., Wang, Q. et al. An evaluation of aging measures: from biomarkers to clocks. Biogerontology 24, 303–328 (2023). https://doi.org/10.1007/s10522-022-09997-4
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DOI: https://doi.org/10.1007/s10522-022-09997-4