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Biomarkers of aging, life span and spontaneous carcinogenesis in the wild type and HER-2 transgenic FVB/N female mice

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Abstract

FVB/N wild type and transgenic HER-2/neu FVB/N female mice breed at N.N. Petrov Research Institute of Oncology were under observation until natural death without any special treatment. Age-related dynamics of body weight, food consumption and parameters of carbohydrate and lipid metabolism, level of nitric oxide, malonic dialdehyde, catalase, Cu, Zn-superoxide dismutase, vascular endothelial growth factor were studied in both mice strains. The parameters of life span and tumor pathology were studied as well. Cancer-prone transgenic HER-2/neu mice developed in 100 % multiple mammary adenocarcinomas and died before the age of 1 year. Forty tree percent of long-lived wild type mice survived the age of 2 years and 19 %—800 days. The total tumor incidence in wild type mice was 34 %. The age-associated changes in the level of serum IGF-1, glucose and insulin started much earlier in transgene HER-2/neu mice as compared with wild type FVB/N mice. It was suggested that transgenic HER-2/neu involves in initiation of malignization of mammary epithelial cells but also in acceleration of age-related hormonal and metabolic changes in turn promoting mammary carcinogenesis.

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Authors and Affiliations

  1. Department of Carcinogenesis and Oncogerontology, N.N.Petrov Research Institute of Oncology, Leningradskaya Str., 68, Pesochny-2, St. Petersburg, Russia, 197758

    Andrey V. Panchenko, Irina G. Popovich, Peter A. Egormin, Maria N. Yurova, Margarita L. Tyndyk, Ekaterina A. Gubareva, Ilia N. Artyukin, Mark A. Zabezhinski & Vladimir N. Anisimov

  2. St.Petersburg State Pediatric Medical University, 2, Litovskaya str., St. Petersburg, Russia, 194100

    Alexandr P. Trashkov, Andrey G. Vasiliev & Nikolai V. Khaitsev

Authors
  1. Andrey V. Panchenko
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  2. Irina G. Popovich
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  3. Alexandr P. Trashkov
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  4. Peter A. Egormin
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  5. Maria N. Yurova
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  6. Margarita L. Tyndyk
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  7. Ekaterina A. Gubareva
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  8. Ilia N. Artyukin
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  9. Andrey G. Vasiliev
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  10. Nikolai V. Khaitsev
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  11. Mark A. Zabezhinski
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  12. Vladimir N. Anisimov
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Correspondence to Vladimir N. Anisimov.

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Panchenko, A.V., Popovich, I.G., Trashkov, A.P. et al. Biomarkers of aging, life span and spontaneous carcinogenesis in the wild type and HER-2 transgenic FVB/N female mice. Biogerontology 17, 317–324 (2016). https://doi.org/10.1007/s10522-015-9611-y

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  • DOI: https://doi.org/10.1007/s10522-015-9611-y

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