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Methods of Testing Pharmacological Drugs Effects on Aging and Life Span in Mice

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Biological Aging

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1048))

Abstract

The methodology of testing antiaging drugs in laboratory mice is presented. It is based on more than 40-year-long authors’ experience in the field and includes the selection of mouse strain, sex, age at start of treatment, housing conditions, design of the long-term study, some noninvasive methods of assessment of biomarkers of aging, life-span parameters, pathology examination, and statistical treatment of the results.

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Acknowledgments

This chapter was supported in part by grants # 14.740,11.0115 from the Russian Federation Ministry of Education and Science, # 11-04-00317 from the Russian Foundation for Basic Research, and grant # NSh-6383.2012.4 from the President of Russian Federation.

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Authors and Affiliations

  1. Department of Carcinogenesis and Oncogerontology, N.N. Petrov Research Institute of Oncology, St. Petersburg, Russia

    Vladimir N. Anisimov, Irina G. Popovich & Mark A. Zabezhinski

Authors
  1. Vladimir N. Anisimov
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  2. Irina G. Popovich
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  3. Mark A. Zabezhinski
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Editors and Affiliations

  1. Dept. Biology, University of Alabama, Birmingham Dept. Biology, Birmingham, Alabama, USA

    Trygve O. Tollefsbol

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Anisimov, V.N., Popovich, I.G., Zabezhinski, M.A. (2013). Methods of Testing Pharmacological Drugs Effects on Aging and Life Span in Mice. In: Tollefsbol, T. (eds) Biological Aging. Methods in Molecular Biology, vol 1048. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-556-9_12

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  • DOI: https://doi.org/10.1007/978-1-62703-556-9_12

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-555-2

  • Online ISBN: 978-1-62703-556-9

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