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Features of Remyelination after Transplantation of Olfactory Ensheathing Cells with Neurotrophic Factors into Spinal Cord Cysts

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Bulletin of Experimental Biology and Medicine Aims and scope

This paper shows for the first time that co-transplantation of human olfactory ensheathing cells with neurotrophin-3 into spinal cord cysts is more effective for activation of remyelination than transplantation of cells with brain-derived neurotrophic factor and a combination of these two factors. The studied neurotrophic factors do not affect proliferation and migration of ensheathing cells in vitro. It can be concluded that the maximum improvement of motor function in rats receiving ensheathing cells with neurotrophin-3 is largely determined by activation of remyelination.

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Authors and Affiliations

  1. V. P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia

    O. V. Stepanova, G. A. Fursa, E. K. Karsuntseva, S. S. Andretsova, A. V. Chadin, A. D. Voronova, V. S. Shishkina, A. S. Semkina & V. P. Chekhonin

  2. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia

    A. S. Semkina & V. P. Chekhonin

  3. University Clinical Hospital, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

    I. V. Reshetov

  4. M. V. Lomonosov Moscow State University, Moscow, Russia

    S. S. Andretsova

  5. E. I. Chazov National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia

    O. V. Stepanova

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  1. O. V. Stepanova
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  2. G. A. Fursa
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  6. A. D. Voronova
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Correspondence to E. K. Karsuntseva.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 4, pp. 242-248, December, 2023

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Stepanova, O.V., Fursa, G.A., Karsuntseva, E.K. et al. Features of Remyelination after Transplantation of Olfactory Ensheathing Cells with Neurotrophic Factors into Spinal Cord Cysts. Bull Exp Biol Med 176, 666–671 (2024). https://doi.org/10.1007/s10517-024-06088-x

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  • DOI: https://doi.org/10.1007/s10517-024-06088-x

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