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The Effect of Transplantation of Olfactory Ensheathing Cells on the Size of Posttraumatic Spinal Cord Cysts

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of transplantation of ensheathing cells obtained from the olfactory mucosa of rats and humans on the size of posttraumatic spinal cord cysts. MRI examination showed that transplantation of these cells into experimental posttraumatic cysts of the spinal cord led to a significant decrease in cyst volume and even their complete disappearance in two animals receiving transplantation of rat or human cells. These findings attested to regenerative processes developing as a result of ensheathing cell transplantation. Further studies in this field will be aimed at elucidation of the mechanisms underlying spinal cord regeneration in the area of posttraumatic cysts after transplantation of ensheathing cells.

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Authors and Affiliations

  1. V. P. Serbsky National Medical Research Center of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia

    A. D. Voronova, O. V. Stepanova, A. V. Chadin, G. A. Fursa, E. K. Karsuntseva, M. P. Valikhov, А. S. Semkina & V. P. Chekhonin

  2. N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia

    А. S. Semkina & V. P. Chekhonin

  3. M. V. Lomonosov Moscow State University, Moscow, Russia

    G. A. Fursa & E. K. Karsuntseva

  4. University Clinical Hospital No. 1, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

    I. V. Reshetov

  5. National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia

    O. V. Stepanova & M. P. Valikhov

Authors
  1. A. D. Voronova
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  2. O. V. Stepanova
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  3. A. V. Chadin
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  4. G. A. Fursa
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  5. E. K. Karsuntseva
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  6. M. P. Valikhov
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  7. А. S. Semkina
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  8. I. V. Reshetov
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  9. V. P. Chekhonin
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Corresponding author

Correspondence to A. D. Voronova.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 1, pp. 18-23, March, 2021

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Voronova, A.D., Stepanova, O.V., Chadin, A.V. et al. The Effect of Transplantation of Olfactory Ensheathing Cells on the Size of Posttraumatic Spinal Cord Cysts. Bull Exp Biol Med 171, 122–126 (2021). https://doi.org/10.1007/s10517-021-05183-7

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  • DOI: https://doi.org/10.1007/s10517-021-05183-7

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