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Killer Function of Circulating Neutrophils in Relation to Cytokines in Uterine Myoma and Endometrial Cancer

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The study presents the killer functions of circulating neutrophils: myeloperoxidase activity, the ability to generate ROS, phagocytic activity, receptor status, NETosis, as well as the level of cytokines IL-2, IL-4, IL-6, IL-17A, and IL-18, granulocyte CSF, monocyte chemotactic protein 1, and neutrophil elastase in the serum of patients with uterine myoma and endometrial cancer (FIGO stages I-III). The phagocytic ability of neutrophils in uterine myoma was influenced by serum levels of granulocyte CSF and IL-2 in 54% of the total variance. The degranulation ability of neutrophils in endometrial cancer was determined by circulating IL-18 in 50% of the total variance. In uterine myoma, 66% of the total variance in neutrophil myeloperoxidase activity was explained by a model dependent on blood levels of IL-17A, IL-6, and IL-4. The risk of endometrial cancer increases when elevated levels of monocyte chemotactic protein 1 in circulating neutrophils are associated with reduced ability to capture particles via extracellular traps (96% probability).

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Authors and Affiliations

  1. Ulyanovsk State University, Ulyanovsk, Russia

    T. V. Abakumova, I. I. Antoneeva & T. P. Gening

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  1. T. V. Abakumova
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  2. I. I. Antoneeva
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  3. T. P. Gening
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Correspondence to T. V. Abakumova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 176, No. 11, pp. 626-631, November, 2023

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Abakumova, T.V., Antoneeva, I.I. & Gening, T.P. Killer Function of Circulating Neutrophils in Relation to Cytokines in Uterine Myoma and Endometrial Cancer. Bull Exp Biol Med 176, 607–611 (2024). https://doi.org/10.1007/s10517-024-06077-0

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  • DOI: https://doi.org/10.1007/s10517-024-06077-0

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