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HIF-1α- and HIF-2α-Immunopositive Neurons and Capillaries in the Prefrontal Cerebral Cortex of Rats with Experimental Myocardial Infarction

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The quantitative content of HIF-1α- and HIF-2α-immunopositive brain neurons in Wistar rats was studied 1, 15, and 30 days after modeling of myocardial infarction. In rats of the control group, the immunohistochemical markers HIF-1α and HIF-2α in the prefrontal cortex of the brain were determined in few pale-colored neurons and capillaries. One day after myocardial infarction simulation, the number of HIF-1α+ neurons increased, and on day 15 it reached the maximum level: the concentration of immunopositive neurons and capillaries increased by 24.7 and 18.4%, respectively, in comparison with the control. After 30 days, the number of HIF-1α+ structures decreased, but remained above the control values. The number of neurons and capillaries positively stained for HIF-2α peaked only on day 30 of the postinfarction period.

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Authors and Affiliations

  1. Department of Human Anatomy, Pacific State Medical University, Ministry of Health of the Russian Federation, Vladivostok, Russia

    V. M. Chertok & A. E. Kotsyuba

  2. Institute of Therapy and Instrumental Diagnostics, Pacific State Medical University, Ministry of Health of the Russian Federation, Vladivostok, Russia

    V. A. Nevzorova

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  1. V. M. Chertok
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  2. V. A. Nevzorova
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  3. A. E. Kotsyuba
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Correspondence to V. M. Chertok.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 1, pp. 117-121, January, 2023

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Chertok, V.M., Nevzorova, V.A. & Kotsyuba, A.E. HIF-1α- and HIF-2α-Immunopositive Neurons and Capillaries in the Prefrontal Cerebral Cortex of Rats with Experimental Myocardial Infarction. Bull Exp Biol Med 175, 101–105 (2023). https://doi.org/10.1007/s10517-023-05819-w

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  • DOI: https://doi.org/10.1007/s10517-023-05819-w

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