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Estimation of the Regenerative Potential of para-Tyrosol in the Model of Testicular Insufficiency Caused by Damage to Spermatogonial Stem Cells

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

The regenerative properties of p-tyrosol were investigated in a model of testicular insufficiency caused by a toxic effect on spermatogonial stem cells (single administration of paclitaxel in the maximum tolerable dose). Against the background of p-tyrosol administration, we observed an increase in the number of normal spermatogonia and Sertoli cells, stimulation of spermatogenesis, and renewal of the spermatogenic tissue. The treatment with p-tyrosol also led to a decrease in DNA damage in cells of the testicular tissue. These changes were accompanied by a decrease in the level of free radicals, an increase in antioxidant protection, and normalization of the redox potential.

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Authors and Affiliations

  1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    T. G. Borovskaya, V. A. Grigor’eva, Yu. A. Shchemerova, S. I. Kamalova, A. V. Vychuzhanina & A. M. Dygai

  2. Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    V. E. Goldberg

  3. Laboratory of Experimental Physiology, Research Institute of Biology and Biophysics, National Research Tomsk State University, Tomsk, Russia

    N. A. Krivova & O. B. Zaeva

Authors
  1. T. G. Borovskaya
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  2. V. A. Grigor’eva
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  3. Yu. A. Shchemerova
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  4. S. I. Kamalova
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  5. A. V. Vychuzhanina
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  6. N. A. Krivova
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  7. O. B. Zaeva
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  8. V. E. Goldberg
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  9. A. M. Dygai
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Corresponding author

Correspondence to T. G. Borovskaya.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 4, pp. 228-232, December, 2021

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Borovskaya, T.G., Grigor’eva, V.A., Shchemerova, Y.A. et al. Estimation of the Regenerative Potential of para-Tyrosol in the Model of Testicular Insufficiency Caused by Damage to Spermatogonial Stem Cells. Bull Exp Biol Med 172, 632–636 (2022). https://doi.org/10.1007/s10517-022-05452-z

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  • DOI: https://doi.org/10.1007/s10517-022-05452-z

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