The effect of phenolic antioxidants (dihydroquercetin, p-tyrosol, dibornol) on the morphology, functions, and redox processes in the reproductive cells of male rats was studied on the model of experimental pathospermia. All antioxidants reduced the percentage of degenerative forms of spermatozoa. Dibornol was most effective. Dihydroquercetin and p-tyrosol did not increase the total number of spermatozoa and the percentage of their mobile forms. These indicators were improved only by dibornol. After administration of all test drugs, the antioxidant potential of spermatozoa increased and did not significantly differ from the baseline values.
Similar content being viewed by others
References
Gol’dberg ED, Borovskaya TG, Timina EA, Fomina TI, Gol’dberg VE. Spermatogenesis in rats after injection of the antitumor drug vepeside. Bull. Exp. Biol. Med. 1997;124(6):1194-1197.
Durnev AD, Smol’nikova NM, Skosyreva AM, Nemova EP, Solomina AS, Shrede OV, Gus’kova TA, Verstakova OL, Syubaev RD. Guidelines for the study of reproductive toxicity of drugs. Manual for Preclinical Studies of New Pharmacological Substances. Mironov AN, ed. Moscow, 2012. P. 80-94.
Evdokimov VV, Aibyabov DT, Turovetskii VB, Andreeva LA, Myasoedov NF, Shmal’gausen EV, Muranets VI. Effects of various factors on human ejaculate parameters in vitro. Andrologiya Genital. Khirurg. 2015;16(4):40-45. Russian.
Yefremov YeA, Kasatonova YV, Melnik YaI. Opportunities of Antioxidant Therapy in Males for Improving Outcome of Assisted Reproductive Technologies. Effekt. Farmakoter. 2017;(22):32-43. Russian.
Men’shchikova EB, Lankin VZ, Kandalintseva NV. Phenolic Antioxidants in Biology and Medicine. Saarbrücken, 2012. Russian.
Trukhan DI, Makushin DG. Role and position of antioxidants in complex therapy of male infertility. Consilium Medicum. 2015;17(7):37-43. Russian.
Shchetinin PP, Shchetinina AP. Mechanisms for the implementation of hindered phenols. Mechanisms underlying antiradical activity of hindered phenols. Aktual. Probl. Gumanit. Estestv. Nauk. 2016;(12-3):112-114. Russian.
Ahmadi S, Bashiri R, Ghadiri-Anari A, Nadjarzadeh A. Antioxidant supplements and semen parameters: An evidence based review. Int. J. Reprod. Biomed. (Yazd). 2016;14(12):729-736.
Bisht S, Faiq M, Tolahunase M, Dada R. Oxidative stress and male infertility. Nat. Rev. Urol. 2017;14(8):470-485.
Kanchana Ganga U, Kishori B, Sreenivasula Reddy P. Cisplatin and/or etoposide induces oxidative stress in testicular, hepatic and kidney tissues in male albino mice. J. Biol. Earth Sci. 2013;3(2):B249-B254.
Muller CH, Lee TK, Montaño MA. Improved Chemiluminescence assay for measuring antioxidant capacity of seminal plasma. Methods Mol. Biol. 2013;927:363-376.
Showell MG, Mackenzie-Proctor R, Brown J, Yazdani A, Stankiewicz MT, Hart RJ. Antioxidants for male subfertility. Cochrane Database Syst. Rev. 2014;(12):CD007411. doi: https://doi.org/10.1002/14651858. CD007411.pub 3.
Velu A, Prasad G. Epidemiologic aspects of male infertility. IJRCOG. 2017;6(8):3362-3365. doi: https://doi.org/10.18203/2320-1770.ijrcog20173446.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 7, pp. 10-13, July, 2018
Rights and permissions
About this article
Cite this article
Borovskaya, T.G., Kamalova, S.I., Krivova, N.A. et al. Experimental Study of the Effectiveness of Phenolic Antioxidants in Male Infertility Caused by Pathospermia. Bull Exp Biol Med 166, 7–10 (2018). https://doi.org/10.1007/s10517-018-4276-6
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-018-4276-6