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Testicular toxicity of cisplatin in rats: ameliorative effect of lycopene and N-acetylcysteine

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Abstract

Lycopene (LP) and N-acetylcysteine (NAC) protective effects were assessed for testicular toxicity mediated by cisplatin (CP) in rats. Forty-nine rats were divided into 7 groups (n = 7); these groups included the control group (saline, PO), LP (10 mg/kg, PO), NAC (150 mg/kg, PO), CP (7.5 mg/kg, IP) on the 27th day of the study, LP + CP, NAC+CP, and LP + NAC + CP. Serum levels of testosterone were decreased following CP injection. Malondialdehyde (MDA) has been increased with considerable glutathione (GSH), and dismutase superoxide (SOD) and catalase (CAT) decline in the testis tissues after CP injection. CP caused severe alterations in testicular tissues and elevated caspase-3 expression. Besides that, LP and/or NAC administration improved CP-induced testicular toxicity and apoptosis, probably via their antioxidant properties.

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Funding

Taif University Researchers Supporting Project number (TURSP-2020/57), Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Qalyubiyya, 13736, Egypt

    Asmaa Elsayed, Ashraf Elkomy & Mohamed Aboubakr

  2. Department of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia

    Mohamed Alkafafy

  3. Department of Histology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Qalyubiyya, 13736, Egypt

    Reda Elkammar

  4. Anatomy Department, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Qalyubiyya, 13736, Egypt

    Anwar El-Shafey

  5. Pharmacology Department, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt

    Ahmed Soliman

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  1. Asmaa Elsayed
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  2. Ashraf Elkomy
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  3. Mohamed Alkafafy
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  4. Reda Elkammar
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  5. Anwar El-Shafey
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  7. Mohamed Aboubakr
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Contributions

Elsayed A, Alkafafy M, El-Shafey A, Soliman A, Elkomy A, and Aboubakr M made design, analysis, and writing. Elkammar R performed pathology and IHC.

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Correspondence to Mohamed Aboubakr.

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Elsayed, A., Elkomy, A., Alkafafy, M. et al. Testicular toxicity of cisplatin in rats: ameliorative effect of lycopene and N-acetylcysteine. Environ Sci Pollut Res 29, 24077–24084 (2022). https://doi.org/10.1007/s11356-021-17736-4

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