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The Study of Efficiency of the Approach to Prevent the Adhesions in the Abdominal Cavity of Rats

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Adhesions in rat abdominal cavity were studied after laparotomy and subsequent single intraperitoneal injection of 2 ml of 5% aqueous solution of oxidized dextran (OD) with a molecular weight of 40 kDa (oxidation degree 10%). On days 7 and 21 after laparotomy, the number of adhesions in OD-treated rats was lower by 7.5 and 4 times than in animals not receiving OD. The number of neutrophils in adhesions on day 21 was manyfold lower in OD-treated rats. In 7 and 21 days after laparotomy, the number of fibroblasts in the adhesions of rats receiving and not receiving OD was similar, but 2-fold higher than in the peritoneum of non-operated rats. The content of collagen in adhesions on day 21 after laparotomy in OD-treated rats was 10-fold lower than in animals no receiving OD.

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Authors and Affiliations

  1. Research Institute of Experimental and Clinical Medicine, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia

    M. A. Karpov, V. A. Shkurupy & A. V. Troitskii

  2. Novosibirsk State Medical University, Ministry of the Health of the Russian Federation, Novosibirsk, Russia

    M. A. Karpov & V. A. Shkurupy

Authors
  1. M. A. Karpov
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  2. V. A. Shkurupy
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  3. A. V. Troitskii
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Correspondence to M. A. Karpov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 171, No. 4, pp. 418-423, April, 2021

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Karpov, M.A., Shkurupy, V.A. & Troitskii, A.V. The Study of Efficiency of the Approach to Prevent the Adhesions in the Abdominal Cavity of Rats. Bull Exp Biol Med 171, 416–420 (2021). https://doi.org/10.1007/s10517-021-05240-1

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  • DOI: https://doi.org/10.1007/s10517-021-05240-1

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