Skip to main content

Advertisement

SpringerLink
Log in

Ultrastructural characteristics of type A epithelioid cells during BCG-granulomatosis and treatment with lysosomotropic isoniazid

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

We studied BCG-granulomas, their cellular composition, and ultrastructure of type A epithelioid cells in the liver of male BALB/c mice with spontaneous granulomatous inflammation. The animals received free isoniazid or isoniazid conjugated with lysosomotropic intracellularly prolonged matrix (dialdehyde dextran, molecular weight 65–75 kDa). Lysosomotropic isoniazid was accumulated in the vacuolar apparatus of epithelioid cells and produced a stimulatory effect on plastic processes in these cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. O. V. Volkova and Yu. K. Eletskii, Bases of Histology and Histological Technique [in Russian], Moscow (1971).

  2. A. A. Mironov, Ya. Yu, Komissarchik, and V. A. Mironov, Methods of Electron Microscopy in Biology and Medicine [in Russian], St. Petersburg (1994).

  3. P. N. Filimonov, V. A. Shkurupii, Yu. N. Kurunov, et al., Probl. Tuberkuleza, No. 1, 63–65 (1999).

  4. V. A. Shkurupii, Yu. N. Kurunov, and S. A. Arkhipov, Ibid., No. 2, 54–56 (1997).

  5. V. A. Shkurupii, Yu. N. Kurunov, and N. N. Yakovchenko, Lysosomotropism: Problems of Cell Physiology and Medicine [in Russian], Novosibirsk (1999).

  6. V. A. Shkurupii, Ya. Yu. Ovsyanko, E. V. Ovsyanko, and A. N. Mashak, Byull. Eksp. Biol. Med., 31, No. 2, 201–204 (2001).

    Google Scholar 

  7. V. A. Shkurupii, P. N. Filimonov, and Yu. N. Kurunov, Probl. Tuberkuleza, No. 6, 63–65 (1998).

  8. D. L. Boros, Granulomatous Infections and Inflammations: Cellular and Molecular Mechanisms, Ed. D. L. Boros, Washington (2003).

Download references

Author information

Authors and Affiliations

  1. Department of General Pathology, Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Russia

    V. A. Shkurupii

  2. Department of Pathoanatomy, Novosibirsk State Medical Academy, Novosibirsk

    M. A. Kozyaev & A. P. Nadeev

Authors
  1. V. A. Shkurupii
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. A. Kozyaev
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. P. Nadeev
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to V. A. Shkurupii.

Additional information

__________

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 4, pp. 474–477, April, 2006

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shkurupii, V.A., Kozyaev, M.A. & Nadeev, A.P. Ultrastructural characteristics of type A epithelioid cells during BCG-granulomatosis and treatment with lysosomotropic isoniazid. Bull Exp Biol Med 141, 487–490 (2006). https://doi.org/10.1007/s10517-006-0206-0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-006-0206-0

Key Words

Search

Navigation