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Study of Immunotropic Properties of Water-Soluble Polysaccharides Isolated from Conium maculatum Grass

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Addition of water-soluble polysaccharides isolated from Conium maculatum L. to the mouse peritoneal macrophage culture induces classical activation of antigen-presenting cells due to an increase in NO synthase activity and a decrease in arginase expression.

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References

  1. Bulgakov TV, Kudashkina NV, Khasanova SR, Belousov MV, Krivoshchekov SV. Study on the polysaccharides of Conium maculatum L. grass. Traditsionnaya Meditsina. 2015;(4):56-59. Russian.

  2. Danilets MG, Bel’skaya NV, Bel’skii YuP, Uchasova EG, Trofimova ES, Ligacheva AA, Gur’ev AM, Belousov MV, Akhmedzhanov RR, Yusubov MS, Agafonov VI. Effect of water-soluble plant polysaccharides on NO-synthase and arginase of mouse macrophages. Vestn. Ural. Med. Akad. Nauki. 2009;(2):49-50. Russian.

  3. Decote-Ricardo D, LaRocque-de-Freitas IF, Rocha JDB, Nascimento DO, Nunes MP, Morrot A, Freire-de-Lima L, Previato JO, Mendonça-Previato L, Freire-de-Lima CG. Immunomodulatory role of capsular polysaccharides constituents of Cryptococcus neoformans. Front. Med. (Lausanne). 2019;6. ID 129. https://doi.org/10.3389/fmed.2019.00129

  4. Górska S, Hermanova P, Ciekot J, Schwarzer M, Srutkova D, Brzozowska E, Kozakova H, Gamian A. Chemical characterization and immunomodulatory properties of polysaccharides isolated from probiotic Lactobacillus casei LOCK 0919. Glycobiology. 2016;26(9):1014-1024.

    Article  Google Scholar 

  5. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite and 15N nitrite in biological fluids. Anal. Biochem. 1982;126(1):131-143.

    Article  CAS  Google Scholar 

  6. Kouakou K, Schepetkin IA, Yapi A, Kirpotina LN, Jutila MA, Quinn MT. Immunomodulatory activity of polysaccharides isolated from Alchornea cordifolia. J. Ethnopharmacol. 2013;146(1):232-242.

    Article  CAS  Google Scholar 

  7. Medzhitov R. Toll-like receptors and innate immunity. Nat. Rev. Immunol. 2001;1(2):135-145.

    Article  CAS  Google Scholar 

  8. Mosmann TR. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immnol. Methods. 1983;65(1-2):55-63.

    Article  CAS  Google Scholar 

  9. Munder M, Eichmann K, Modolell M. Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype. J. Immunol. 1998;160(11):5347-5354.

    CAS  PubMed  Google Scholar 

  10. Schepetkin IA, Quinn MT. Botanical polysaccharides: macrophage immunomodulation and therapeutic potential. Int. Immunopharmacol. 2006;6(3):317-333.

    Article  CAS  Google Scholar 

  11. Schepetkin IA, Xie G, Kirpotina LN, Klein RA, Jutila MA, Quinn MT. Macrophage immunomodulatory activity of polysaccharides isolated from Opuntia polyacantha. Int. Immunopharmacol. 2008;8(10):1455-1466.

    Article  CAS  Google Scholar 

  12. Sharma JN, Al-Omran A, Parvathy SS. Role of nitric oxide in inflammatory diseases. Inflammopharmacology. 2007;15(6):252-259.

    Article  CAS  Google Scholar 

  13. Shreshtha S, Sharma P, Kumar P, Sharma R, Singh SP. Nitric Oxide: It’s role in immunity. J. Clin. Diagn. Res. 2018;12(7):BE01-BE05. https://doi.org/10.7860/JCDR/2018/31817.11764

    Article  CAS  Google Scholar 

  14. Tong H, Mao D, Zhai M, Zhang Z, Sun G, Jiang G. Macrophage activation induced by the polysaccharides isolated from the roots of Sanguisorba officinalis. Pharm. Biol. 2015;53(10):1511-1515.

    Article  CAS  Google Scholar 

  15. Tripathi P, Tripathi P, Kashyap L, Singh V. The role of nitric oxide in inflammatory reactions. FEMS Immunol. Med. Microbiol. 2007;51(3):443-452.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    A. A. Ligacheva, E. Yu. Sherstoboev, M. G. Danilets & E. S. Trofimova

  2. Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia

    S. V. Krivoshchekov, A. M. Gur’ev, A. G. Miroshnichenko & M. V. Belousov

  3. Bashkir State Medical University, Ministry of Health of the Russian Federation, Ufa, Russia

    T. V. Bulgakov & N. V. Kudashkina

Authors
  1. A. A. Ligacheva
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  2. E. Yu. Sherstoboev
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  3. M. G. Danilets
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  4. E. S. Trofimova
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  5. S. V. Krivoshchekov
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  6. A. M. Gur’ev
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  7. T. V. Bulgakov
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  8. N. V. Kudashkina
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  9. A. G. Miroshnichenko
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  10. M. V. Belousov
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Corresponding author

Correspondence to E. Yu. Sherstoboev.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 8, pp. 168-172, August, 2020

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Ligacheva, A.A., Sherstoboev, E.Y., Danilets, M.G. et al. Study of Immunotropic Properties of Water-Soluble Polysaccharides Isolated from Conium maculatum Grass. Bull Exp Biol Med 170, 203–206 (2020). https://doi.org/10.1007/s10517-020-05033-y

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  • DOI: https://doi.org/10.1007/s10517-020-05033-y

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