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Comparative Analysis of Cardiac Effects of α1A-Adrenoreceptor Stimulation In Vivo and Ex Vivo in Newborn Rats

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The study examined the effects of α1A-adrenoceptor stimulation on chronotropic function of Langendorff-perfused isolated heart ex vivo and on cardiac chronotropy in vivo in 7-day-old rats. α1A-Adrenergic receptor agonist A-61603 reduced heart chronotropy only in the whole organism. No chronotropic effects of selective stimulation of α1A-adrenergic receptors on isolated hearts were observed in ex vivo experiments. These findings suggest that α1A-adrenergic receptors are not implicated in HR regulation in newborn rats. Bradycardia induced by activation of these receptors in vivo is most likely associated with reflex influences on the heart and changes in the vascular tone in the whole organism.

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Authors and Affiliations

  1. Department of Human Health Protection, Kazan (Volga Region) Federal University, Kazan, Russia

    I. I. Khabibrakhmanov, N. I. Ziyatdinova & T. L. Zefirov

  2. Department of Normal Physiology, Kazan Federal Medical University, Ministry of Health of the Russian Federation, Kazan, Republic of Tatarstan, Russia

    A. L. Zefirov

Authors
  1. I. I. Khabibrakhmanov
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  2. N. I. Ziyatdinova
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  3. A. L. Zefirov
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  4. T. L. Zefirov
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Correspondence to T. L. Zefirov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 5, pp. 532-535, May, 2020

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Khabibrakhmanov, I.I., Ziyatdinova, N.I., Zefirov, A.L. et al. Comparative Analysis of Cardiac Effects of α1A-Adrenoreceptor Stimulation In Vivo and Ex Vivo in Newborn Rats. Bull Exp Biol Med 169, 605–608 (2020). https://doi.org/10.1007/s10517-020-04937-z

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  • DOI: https://doi.org/10.1007/s10517-020-04937-z

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