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Comparative Analysis of the Impact of α1- and α2-Adrenoreceptor Blockade on Cardiac Function in Rats during Postnatal Ontogeny

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We compared the effects of α1-and α2-adrenoreceptor blockade on cardiac function in rats aged 1, 3, 6 and 20 weeks. Administration of α1-adrenoblocker prazosin decreased heart rate in 20- and 6-week-old rats; in 3-week-old rats, this decrease was insignificant and in 1-weekold rats was absent. Blockade of α2-adrenoreceptors with yohimbine did not change heart rate in 6- and 20-week-old rats and induced bradycardia in 1- and 3-week old rats.

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Authors and Affiliations

  1. Department of Anatomy, Physiology, and Human Health Protection, State Pedagogical University, Kazan, Russia

    T. L. Zefirov, N. I. Ziatdinova & L. I. Khisamieva

  2. Department of Normal Physiology, Kazan State Medical University, Kazan, Russia

    A. L. Zefirov

Authors
  1. T. L. Zefirov
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  2. N. I. Ziatdinova
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  3. L. I. Khisamieva
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  4. A. L. Zefirov
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Correspondence to T. L. Zefirov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 151, No. 6, pp. 607–610, June 2011

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Zefirov, T.L., Ziatdinova, N.I., Khisamieva, L.I. et al. Comparative Analysis of the Impact of α1- and α2-Adrenoreceptor Blockade on Cardiac Function in Rats during Postnatal Ontogeny. Bull Exp Biol Med 151, 664–666 (2011). https://doi.org/10.1007/s10517-011-1410-0

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  • DOI: https://doi.org/10.1007/s10517-011-1410-0

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