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Influence of Al3+, Fe3+ and Zn2+ Ions on Phosphorylation of Tubulin and Microtubulo-Associated Proteins of Rat Brain

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Phosphorylation of τ-protein, a component of microtubules in brain neurons, is a key pathomorphological sign of Alzheimer’s disease. The development of this intracellular defect can be promoted by Al3+, Fe3+, and Zn2+ ions. The concentrations of these ions in the brain are considerably elevated in Alzheimer’s disease. We performed a comparative study of phosphorylation of microtubular proteins of rat brain in the presence of Al3+, Fe3+, and Zn2+ ions in concentrations of 10-500 μM and microtubular proteins of brain of patients with Alzheimer’s disease. The most likely candidate for the role of a factor that promotes hyperphosphorylation of τ-protein is Al3+ in concentrations of 250 and 500 μM.

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Authors and Affiliations

  1. Laboratory of Neurochemistry, Research Center for Mental Health, Moscow, Russia

    P. N. Shevtsov, O. K. Savushkina & G. Sh. Burbaeva

  2. Laboratory of Biomolecular Screening, Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia

    E. F. Shevtsova & S. O. Bachurin

Authors
  1. P. N. Shevtsov
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  2. E. F. Shevtsova
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  3. O. K. Savushkina
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  4. G. Sh. Burbaeva
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  5. S. O. Bachurin
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Correspondence to P. N. Shevtsov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 4, pp. 509-512, April, 2018

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Shevtsov, P.N., Shevtsova, E.F., Savushkina, O.K. et al. Influence of Al3+, Fe3+ and Zn2+ Ions on Phosphorylation of Tubulin and Microtubulo-Associated Proteins of Rat Brain. Bull Exp Biol Med 165, 512–515 (2018). https://doi.org/10.1007/s10517-018-4206-7

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  • DOI: https://doi.org/10.1007/s10517-018-4206-7

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