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Analysis of Blood Plasma Protein Composition in Patients with Cerebral Ischemia

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Blood plasma proteome in patients with cerebral ischemia and healthy individuals was studied using comparative proteomic analysis based on tandem HPLC-MS/MS. Mass spectra were analysed in an automated mode using Progenesis LS-MS software and 256 proteins were identified. Significant quantitative differences were revealed for 20 proteins. It was found that changes in the blood plasma proteome in subjects with cerebral ischemia involved a wide range of proteins: molecular chaperones, fibrinolysis, angiogenesis, and immune system proteins, proteins involved in homeostasis maintenance, cell differentiation and proliferation, regulators of apoptosis, and cytoskeleton proteins.

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Authors and Affiliations

  1. V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia

    Yu. S. Kisrieva, N. A. Petushkova, N. F. Samenkova, G. P. Kuznetsova, O. V. Larina, V. G. Zgoda & I. I. Karuzina

  2. N. N. Burdenko National Research and Practical Centre for Neurosurgery, Ministry of Health of the Russian Federation, Moscow, Russia

    N. B. Teryaeva, D. U. Usachev & A. Yu. Belyaev

Authors
  1. Yu. S. Kisrieva
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  2. N. A. Petushkova
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  3. N. F. Samenkova
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  4. G. P. Kuznetsova
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  5. O. V. Larina
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  6. N. B. Teryaeva
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  7. V. G. Zgoda
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  8. I. I. Karuzina
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  9. D. U. Usachev
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  10. A. Yu. Belyaev
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Corresponding author

Correspondence to Yu. S. Kisrieva.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 1, pp. 29-33, January, 2018

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Kisrieva, Y.S., Petushkova, N.A., Samenkova, N.F. et al. Analysis of Blood Plasma Protein Composition in Patients with Cerebral Ischemia. Bull Exp Biol Med 165, 22–26 (2018). https://doi.org/10.1007/s10517-018-4090-1

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  • DOI: https://doi.org/10.1007/s10517-018-4090-1

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