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Dynamics of Distribution of Capillaries with Matrix Metalloproteinase-2 and Its Tissue Inhibitor in Rat Brain during Development of Experimental Hypertension

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The capillaries containing MMP-2 and its tissue inhibitor TIMP-2 were examined in cerebral cortex and white matter obtained from intact Wistar rats (n=5) and the rats with progressing experimental renovascular hypertension (n=35). In hypertensive rats, the changes in intensity of the immunohistochemical reaction and in the density of capillaries expressing TIMP-2 significantly differed from the corresponding values in MMP-2-positive capillaries, which resulted in pronounced deviation of MMP-2/TIMP-2 index from the control level (especially in cerebral cortex) probably attesting to enhanced risk of complications in cases with arterial hypertension.

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Authors and Affiliations

  1. Department of Human Anatomy, Vladivostok, Russia

    V. M. Chertok & A. G. Chertok

  2. Institute of Therapy and Instrumental Diagnostics, Pacific State Medical University, Ministry of Health of the Russian Federation, Vladivostok, Russia

    N. V. Zakharchuk & V. A. Nevzorova

Authors
  1. V. M. Chertok
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  2. A. G. Chertok
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  3. N. V. Zakharchuk
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  4. V. A. Nevzorova
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Correspondence to V. M. Chertok.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 9, pp. 385-389, September, 2017

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Chertok, V.M., Chertok, A.G., Zakharchuk, N.V. et al. Dynamics of Distribution of Capillaries with Matrix Metalloproteinase-2 and Its Tissue Inhibitor in Rat Brain during Development of Experimental Hypertension. Bull Exp Biol Med 164, 397–401 (2018). https://doi.org/10.1007/s10517-018-3998-9

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  • DOI: https://doi.org/10.1007/s10517-018-3998-9

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