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Distribution of Heme Oxygenases in the Walls of the Arteries of the Pia Mater of the Brain

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The locations of heme oxygenase-2 (HO-2) and heme oxygenase-1 (HO-1) in the walls of 1st- to 4th-order arterial branches in the pia mater were studied in normotensive rats and in animals with induced renovascular hypertension (RVH). Immunohistochemical detection of heme oxygenase was performed on 40 Wistar rats. The vasomotor function of carbon monoxide (CO) in 3rd- to 5th-order arteries was found to be associated mainly with the endothelium, while in 1st- and 2nd-order arteries it was associated with myocytes. In normotensive animals, HO-2 was involved in forming CO, while both HO-2 and HO-1 had roles in hypertensive animals. The largest number of vessels expressing HO-1 was seen in week 16 of RVH, when the proportion of vessels positive for HO-2 was minimal, which is consistent with the time at which arterial pressure stabilizes at the new, higher, level.

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References

  1. A. A. Afanas’ev and V. M. Chertok, “Use of the Allegro-MC automatic image analysis system for quantitative biomicroscopy of the microcirculatory bed,” Tikhookeansk. Med. Zh., No. 2, 82–86 (2004).

  2. A. E. Kotsyuba and V. M. Chertok, “Distribution of heme oxygenase-2 in the nuclei of the rat brain,” Morfologiya, 142, No. 6, 15–19 (2012).

    Google Scholar 

  3. A. E. Kotsyuba, V. M. Chertok, and A. G. Chertok, “Developmental features of CO-mediated reactions of pial arteries of different diameters in rats,” Byull. Eksperim. Biol., 162. No. 11, 612–617 (2011).

    Google Scholar 

  4. V. M. Chertok and A. E. Kotsyuba, “Developmental features of the vasomotor regulation of pia mater arteries in the rat brain,” Byull. Eksperim. Biol., 149. No. 3, 340–344 (2010).

    Google Scholar 

  5. V. M. Chertok and A. E. Kotsyuba, “Changes in inducible NO synthase in pial arteries of different diameters in hypertensive rats,” Byull. Eksperim. Biol., 152. No. 8, 220–223 (2011).

    Google Scholar 

  6. V. M. Chertok and A. E. Kotsyuba, “Endothelial (intimal) mechanisms of regulation of cerebral hemodynamics: a paradigm shift,” Tikhookeansk. Med. Zh., No. 2, 17–26 (2012).

  7. V. M. Chertok, A. E. Kotsyuba, and E. P. Kotsyuba, “Heme oxygenase-2 in neurons in the human brain and spinal cord,” Vestn. Ross. Akad. Med. Nauk, No. 6, 36–41 (2012).

  8. V. M. Chertok and A. G. Chertok, “The regulatory potential of capillaries in the brain,” Tikhookeansk. Med. Zh., No. 2, 72–81 (2016).

  9. J. J. Andresen, N. I. Shafi, W. Durante, and R. M. Bryan, Jr., “Effects of carbon monoxide and heme oxygenase inhibitors in cerebral vessels of rats and mice,” Am. J. Physiol. Heart Circ. Physiol., 291, No. 1, H223–H230 (2006).

    Article  CAS  PubMed  Google Scholar 

  10. Y. Chen, F. Huang, and Wang D., “Upregulation of heme oxygenase-1 expression may facilitate memory and learning in mice,” Exp. Ther. Med., 5, No. 5, 1491–1495 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. J. F. Ewing and M. D. Maines, “Regulation and expression of heme oxygenase enzymes in aged-rat brain: age related depression in HO-1 and HO-2 expression and altered stress-response,” J. Neural. Transm., 113, No. 4, 439–454 (2006).

    Article  CAS  PubMed  Google Scholar 

  12. L. E. Fredenburgh, A. A. Merz, and S. Cheng, “Haeme oxygenase signalling pathway: implications for cardiovascular disease,” J. Eur. Heart., 36, No. 24, 1512–1518 (2015).

    Article  CAS  Google Scholar 

  13. D. D. Haines, I. Lekli, P. Teissier, et al., “Role of haeme oxygenase-1 in resolution of oxidative stress-related pathologies: focus on cardiovascular, lung, neurological and kidney disorders,” Acta Physiol., 204, No. 4, 487–501 (2012).

    Article  CAS  Google Scholar 

  14. W. Jones, W. Durante, and R. J. Korthuis, “Heme oxygenase-1 deficiency leads to alteration of soluble guanylate cyclase redox regulation,” J. Pharmacol. Exp. Ther., 335, No. 1, 85–91 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. C. W. Leffler, H. Parfenova, and J. H. Jaggar, “Carbon monoxide as an endogenous vascular modulator,” Am. J. Physiol. Heart Circ. Physiol., 301, No. 1, H1–H11 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. D. G. Levitt and M. D. Levitt, “Carbon monoxide: a critical quantitative analysis and review of the extent and limitations of its second messenger function,” Clin. Pharmacol., 26, No. 7, 37–56 (2015).

    Google Scholar 

  17. M. D. Maines, “The heme oxygenase system, past, present and future,” Antioxid. Redox Signal., 6, No. 5, 797–801 (2004).

    Article  CAS  PubMed  Google Scholar 

  18. J. S. Naik, T. L. O’Donaughy, and B. R. Walker, “Endogenous carbon monoxide is an endothelial-derived vasodilator factor in the mesenteric circulation,” Am. J. Physiol. Heart and Circ. Physiol., 284, No. 3, H838–H845 (2009).

    Article  Google Scholar 

  19. J. F. Ndisang, H. E. Tabien, and R. Wang, “Carbon monoxide and hypertension,” J. Hypertens., 22, No. 6, 1057–1074 (2004).

    Article  CAS  PubMed  Google Scholar 

  20. S. Tiwari and J. F. Ndisang, “Heme oxygenase system and hypertension: a comprehensive insight,” Curr. Pharm. Des., 20, No. 9, 1354–1369 (2014).

    Article  CAS  PubMed  Google Scholar 

  21. M. L. Wu, Y. C. Ho, C. Y. Lin, and S. F. Yet, “Heme oxygenase-1 in inflammation and cardiovascular disease,” Am. J. Cardiovasc. Dis., 1, No. 2, 150–158 (2011).

    CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Human Anatomy, Pacific State Medical University, Vladivostok, Russia

    V. M. Chertok, A. E. Kotsyuba & A. G. Chertok

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  1. V. M. Chertok
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  2. A. E. Kotsyuba
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  3. A. G. Chertok
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Correspondence to V. M. Chertok.

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Translated from Morfologiya, Vol. 151, No. 1, pp. 33–38, January–February, 2017.

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Chertok, V.M., Kotsyuba, A.E. & Chertok, A.G. Distribution of Heme Oxygenases in the Walls of the Arteries of the Pia Mater of the Brain . Neurosci Behav Physi 48, 143–148 (2018). https://doi.org/10.1007/s11055-018-0543-2

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  • DOI: https://doi.org/10.1007/s11055-018-0543-2

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