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Mechanisms of Cerebral Angiogenesis in Health and Brain Pathology

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This literature review assesses the characteristics of the cerebral microcirculatory system. The development and maturation of the microcirculation of the brain includes complex interactions between endothelial cells, which are regulated by all other brain cell types (pericytes, astrocytes, microglia, neurons). The mechanisms by which pericytes are involved in the process of assembly of neurovascular units is discussed, along with the functional importance of the vascular basement membrane in the process of angiogenesis, the role of astrocytes in barrier formation and vessel remodeling, and the involvement of microglia in the processes of forming new vascular connections. This article considers the mechanisms of regulation of cerebral angiogenesis in health and identifies the characteristics of angiogenesis in cerebrovascular diseases.

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  1. Research Institute of Molecular Medicine and Pathobiochemistry, Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation, Krasnoyarsk, Russia

    Yu. A. Uspenskaya, A. V. Morgun, E. D. Osipova, E. A. Pozhilenkova & A. B. Salmina

  2. Krasnoyarsk State Agrarian University, Krasnoyarsk, Russia

    Yu. A. Uspenskaya

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Translated from Uspekhi Fiziologicheskikh Nauk, Vol. 52, No. 2, pp. 39–50, April–June, 2021.

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Uspenskaya, Y.A., Morgun, A.V., Osipova, E.D. et al. Mechanisms of Cerebral Angiogenesis in Health and Brain Pathology. Neurosci Behav Physi 52, 453–461 (2022). https://doi.org/10.1007/s11055-022-01259-7

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