We performed a comparative analysis of physicochemical properties and biocompatibility of scaffolds of different composition on the basis of biodegradable polymers fabricated by casting and electrospinning methods. For production of polyhydroxyalkanoate-based scaffolds by electrospinning method, the optimal concentration of the polymer was 8-10%. Fiber diameter and properties of the scaffold produced by electrospinning method depended on polymer composition. Addition of polycaprolactone increased elasticity of the scaffolds. Bio- and hemocompatibility of the scaffolds largely depended on the composition formulation and method of scaffold fabrication. Polylactide introduced into the composition of polyhydroxybutyrate-oxyvalerate scaffolds accelerated degradation and increased adhesive properties of the scaffolds.
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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 3, pp. 160-166, July, 2015
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Nasonova, M.V., Glushkova, T.V., Borisov, V.V. et al. Biocompatibility and Structural Features of Biodegradable Polymer Scaffolds. Bull Exp Biol Med 160, 134–140 (2015). https://doi.org/10.1007/s10517-015-3114-3
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DOI: https://doi.org/10.1007/s10517-015-3114-3