Skip to main content
SpringerLink
Log in

Expression of Circadian Rhythm Genes CLOCK, BMAL1, and PER1 in Buccal Epithelial Cells of Patients with Essential Arterial Hypertension in Dependence on Polymorphic Variants of CLOCK and BMAL1 Genes

  • GENETICS
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

The transcript levels of circadian rhythm genes CLOCK, BMAL1, and PER1 in buccal epithelial cells of the patients with essential arterial hypertension was analyzed in relation to polymorphic variants of CLOCK and BMAL1 genes. These levels were assessed with realtime PCR method at daily hours 9, 13, and 17. The signifi cant differences were revealed in transcript levels of the examined genes in patients with various genotypes at the polymorphic markers 3111TC and 257TG regulatory regions of CLOCK gene. The study detected no signifi cant differences among the carriers of various genotypes at polymorphic markers 862TC and 2121GA of CLOCK gene and 56445TC of BMAL1 gene.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. I. V. Kurbatova, S. N. Kolomeichuk, L. V. Topchieva, et al., Dokl. Ross. Akad. Nauk, 446, No. 6, 703-706 (2012).

    Google Scholar 

  2. I. V. Kurbatova, L. V. Topchieva, S. N. Kolomeichuk, et al., Actual Problems of Laboratory Diagnostics and Biotechnology. Proceedings of All-Russian Scientifi c and Practical Conference [in Russian], Kemerovo, (2012), pp. 51-52.

  3. B. Etain, A. Dumaine, F. Bellivier, et al., Hum Mol. Genet., 21, No. 18, 4030-4037 (2012).

    Article  CAS  PubMed  Google Scholar 

  4. P. Gómez-Abellán, J. A. Madrid, J. A. Luján, et al., Obes. Surg., 22, No. 1, 105-112 (2012).

    Article  PubMed  Google Scholar 

  5. C. L. Gorman, A. I. Russell, Z. Zhang, et al., J. Immunol., 180, No. 2, 1060-1070 (2008).

    Article  CAS  PubMed  Google Scholar 

  6. S. Kojima, D. L. Shingle, and C. B. Green, J. Cell Sci., 124, No. 3, 311-320 (2011).

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  7. W. Krugluger, A. Brandstaetter, E. Kállay, et al., Cancer Res., 67, No. 16, 7917-7922 (2007).

    Article  CAS  PubMed  Google Scholar 

  8. R. D. Rudic, P. McNamara, D. Reilly, et al., Circulation, 112, No. 17, 2716-2724 (2005).

    Article  CAS  PubMed  Google Scholar 

  9. J. A. Stamenkovic, A. H. Olsson, C. L. Nagorny et al., Metabolism, 61, No. 7, 978-985 (2012).

    Article  CAS  PubMed  Google Scholar 

  10. M. von Schantz, J. Genet., 87, No. 5, 513-519 (2008).

    Article  Google Scholar 

  11. M. E. Young, P. Razeghi, and H. Taegtmeyer, Circ. Res., 88, No. 11, 1142-1150 (2001).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Biology, Karelian Scientific Center, Russian Academy of Sciences, Petrozavodsk, Russia

    I. V. Kurbatova, L. V. Topchieva, S. N. Kolomeichuk & N. N. Nemova

  2. Petrozavodsk State University, Petrozavodsk, Russia

    V. A. Korneva

Authors
  1. I. V. Kurbatova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. V. Topchieva
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. A. Korneva
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. N. Kolomeichuk
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. N. N. Nemova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to I. V. Kurbatova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 3, pp. 339-342, March, 2014

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kurbatova, I.V., Topchieva, L.V., Korneva, V.A. et al. Expression of Circadian Rhythm Genes CLOCK, BMAL1, and PER1 in Buccal Epithelial Cells of Patients with Essential Arterial Hypertension in Dependence on Polymorphic Variants of CLOCK and BMAL1 Genes. Bull Exp Biol Med 157, 360–363 (2014). https://doi.org/10.1007/s10517-014-2566-1

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-014-2566-1

Keywords

Search

Navigation