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Associations between Vitamin D-Binding Protein (DBP) Gene Polymorphism (TAAA)n and Development of Osteoporosis in the Volga-Ural Region of Russia

  • Genetics
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Bulletin of Experimental Biology and Medicine Aims and scope

Study of DBP gene (TAAA) n polymorphism in women of postmenopausal age revealed a significantly lower incidence of DBP * 10 allele and a higher incidence of DBP * 11 allele in Russian women with bone fractures in comparison with the relevant controls (χ2 = 4.47, p = 0.034 and χ2 = 4.28, p = 0.038, respectively). Allele DBP * 11 is a high risk marker (OR = 1.93; 95%CI 1.06-3.48), while allele DBP*10 a marker of low risk of bone fractures (OR = 0.59; 95%CI 0.37-0.94). A trend to a reduction of mineral density of the femoral neck and of the lumbar vertebrae in women with DBP * 10 * 8 genotype of DBP gene polymorphic locus (TAAA) n in comparison with DBP * 10 * 10 and DBP * 10 * 11 genotype carriers is traced.

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Authors and Affiliations

  1. Institute of Biochemistry and Genetics, Ural Research Center, the Russian Academy of Sciences, Ufa, Russia

    R. I. Khusainova, L. I. Seleznyova, R. Ya. Shakirova, R. Z. Nurlygayanov & E. K. Khusnutdinova

  2. Bashkir State University, Ufa, Russia

    R. I. Khusainova, A. V. Mal’tsev, D. D. Nadyrshina & E. K. Khusnutdinova

Authors
  1. R. I. Khusainova
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  2. L. I. Seleznyova
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  3. A. V. Mal’tsev
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  4. R. Ya. Shakirova
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  5. R. Z. Nurlygayanov
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  6. D. D. Nadyrshina
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  7. E. K. Khusnutdinova
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Corresponding author

Correspondence to R. I. Khusainova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 2, pp. 218-222, February, 2014

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Khusainova, R.I., Seleznyova, L.I., Mal’tsev, A.V. et al. Associations between Vitamin D-Binding Protein (DBP) Gene Polymorphism (TAAA)n and Development of Osteoporosis in the Volga-Ural Region of Russia. Bull Exp Biol Med 157, 253–257 (2014). https://doi.org/10.1007/s10517-014-2538-5

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  • DOI: https://doi.org/10.1007/s10517-014-2538-5

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