Plasma LDL content increased in rats with mild chronic heart failure, but decreased in animals with severe pathology. The lipid profi le of β-adrenoceptor antagonists depended on their selectivity. The most selective antagonists of β-adrenoceptors had little effect on the lipid composition. Nonselective β-adrenoceptor antagonists increased the index of plasma atherogenicity, which did not depend on the severity of a pathological process. In mild chronic heart failure, these changes were associated with a decrease in HDL concentration, while in severe chronic heart failure; they were related to a tendency towards a decrease in HDL content and an increase in LDL concentration. The increase in survival rate was associated with true antagonism of the agent to β-adrenoceptors (the absence of intrinsic sympathomimetic activity) and, to a lesser extent, with nonselective blockade of β-adrenoceptors.
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Sidorov, A.V. Effect of Long-Term Treatment with β-Adrenoceptor Antagonists on Blood Lipid Composition and Survival of Rats with Heart Failure of Different Severity . Bull Exp Biol Med 156, 209–212 (2013). https://doi.org/10.1007/s10517-013-2312-0
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DOI: https://doi.org/10.1007/s10517-013-2312-0