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Mechanisms of the Anti-Infl ammatory and Antifi brotic Activity of a Sympatholytic Agent during Toxic Pulmonary Fibrosis

  • GENERAL PATHOLOGY AND PATHOPHYSIOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

The effect of a course treatment with a sympatholytic reserpine on the infl ammatory response and connective tissue proliferation in the lungs of C57Bl/6 mice was studied on the model of toxic pulmonary fi brosis induced by intratracheal administration of bleomycin. This sympatholytic reduced infi ltration of the alveolar interstitium and alveolar ducts with infl ammatory cells (lymphocytes, macrophages, neutrophils, and plasma cells) and prevented connective tissue proliferation in the lungs. The anti-infl ammatory effect of reserpine was associated with a decrease in activity of bone marrow granulocyte-erythroid-macrophage-megakaryocyte and granulocyte precursors (proliferation and mobilization). The antifi brotic effect of reserpine was due to a decrease in the number of committed precursors for mesenchymopoiesis.

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Authors and Affiliations

  1. Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia

    E. G. Skurikhin, E. S. Khmelevskaya, O. V. Pershina, T. V. Andreeva, L. A. Ermolaeva, V. A. Krupin, N. N. Ermakova, A. M. Reztsova, I. E. Stepanova & A. M. Dygai

Authors
  1. E. G. Skurikhin
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  2. E. S. Khmelevskaya
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  3. O. V. Pershina
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  4. T. V. Andreeva
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  5. L. A. Ermolaeva
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  6. V. A. Krupin
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  7. N. N. Ermakova
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  8. A. M. Reztsova
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  9. I. E. Stepanova
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  10. A. M. Dygai
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Corresponding author

Correspondence to O. V. Pershina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 153, No. 5, pp. 590-595, May, 2012

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Skurikhin, E.G., Khmelevskaya, E.S., Pershina, O.V. et al. Mechanisms of the Anti-Infl ammatory and Antifi brotic Activity of a Sympatholytic Agent during Toxic Pulmonary Fibrosis. Bull Exp Biol Med 153, 638–643 (2012). https://doi.org/10.1007/s10517-012-1786-5

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  • DOI: https://doi.org/10.1007/s10517-012-1786-5

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