We studied the effect of apolipoprotein A-I—tetrahydrocortisone complex on 14C glucose absorption and lactate accumulation and on the rate of protein biosynthesis in isolated rat hepatocytes. The presence of apolipoprotein A-I—tetrahydrocortisone complex in the incubation medium increased absorption of labeled glucose by hepatocytes by 52%, while lactate content in the conditioning medium increased 4-fold. The rate of protein biosynthesis increased by 80% in comparison with control cells. It is hypothesized that the increase in protein biosynthesis rate in hepatocytes under the effect of apolipoprotein A-I—tetrahydrocortisone complex is due to stimulation of energy metabolism, specifi cally, of its glycolytic component.
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Sumenkova, D.V., Knyazev, R.A., Guschya, R.S. et al. Effect of Apolipoprotein A-I Complex with Tetrahydrocortisone on Protein Biosynthesis and Glucose Absorption by Rat Hepatocytes. Bull Exp Biol Med 148, 207–209 (2009). https://doi.org/10.1007/s10517-009-0667-z
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DOI: https://doi.org/10.1007/s10517-009-0667-z