Exogenous NO donor 3,3-bis-(nitroxymethyl)oxetane (NMO) was synthesized at the Institute for Problems of Chemical Physics (Russian Academy of Sciences). This compound was shown to inhibit cell death (apoptosis and necrosis) in cyclophosphamidesensitive and cyclophosphamide-resistant P388 murine tumor. p53 protein was expressed in both lines of tumor cells. NO donor NMO had little effect on p53 protein expression in cells of both stains. Our results suggest that the proapoptotic effect of NMO is mediated by the p53-independent molecular mechanisms.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 147, No. 4, pp. 401–403, April, 2009
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Rajewskaya, T.A., Goncharova, S.A., Konovalova, N.P. et al. Effect of Nitric Oxide Donor, a Modulator of Tumor Drug Resistance, on Cell Death and p53 Protein Expression. Bull Exp Biol Med 147, 421–423 (2009). https://doi.org/10.1007/s10517-009-0526-y
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DOI: https://doi.org/10.1007/s10517-009-0526-y