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Increase in tylosin production by a commercial strain of Streptomyces fradiae

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Abstract

Conventional mutagenesis (UV irradiation and exposure to nitrosoguanidine) as well as protoplast formation and regeneration were used to improve the antibiotic activity of a Streptomyces fradiae strain producing tylosin. Variants exceeding the activity of the initial producer strain by 0.5–28.3% were obtained. The most active variants were produced by a combined exposure to UV and nitrosoguanidine, as well as upon regeneration of protoplasts formed from the cells of clones produced by UV irradiation. Unstable inheritance of the trait of increased tylosin production was demonstrated.

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Authors and Affiliations

  1. Institute of Microbiology, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria

    D. G. Lyutskanova, M. M. Stoilova-Disheva & V. T. Peltekova

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  1. D. G. Lyutskanova
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  2. M. M. Stoilova-Disheva
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  3. V. T. Peltekova
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Translated from Prikladnaya Biokhimiya i Mikrobiologiya, Vol. 41, No. 2, 2005, pp. 189–193.

Original Russian Text Copyright © 2005 by Lyutskanova, Stoilova-Disheva, Peltekova.

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Lyutskanova, D.G., Stoilova-Disheva, M.M. & Peltekova, V.T. Increase in tylosin production by a commercial strain of Streptomyces fradiae . Appl Biochem Microbiol 41, 165–168 (2005). https://doi.org/10.1007/s10438-005-0028-2

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  • DOI: https://doi.org/10.1007/s10438-005-0028-2

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