Introduction
More and more colorectal surgeons believe that total mesorectal excision can achieve favorable oncologic results for the treatment of rectal cancers. The present study is a feasibility study aiming to evaluate if total mesorectal excision can be safely performed by laparoscopic approach with beneficial functional recovery.
Methods
A total of 44 patients (from January 2004 to February 2005) with middle rectal cancer (the average distance from anal verge was 7.8 cm, ranging from 5.0 to 10.0 cm) without preoperative chemoradiation therapy were selected to undergo laparoscopic total mesorectal excision. Before the study entry, all patients underwent pelvic magnetic resonance imaging or multislice spiral computed tomography to evaluate the circumferential resection margin of rectal cancer. Only patients whose circumferential resection margin was not involved by rectal cancer were considered as potentially curable by total mesorectal excision procedures and were enrolled for this study. The operation procedures were conducted according to the guidelines advocated by Heald et al.1 and were shown in the video. Posteriorly, the dissection was along the ‘holy plane’ downward to the level of levator ani muscle. Anteriorly, the dissection plane was at the anterior part of Denonvilliers fascia. Laterally, the lateral ligaments were sharply cauterized at the medial part. The resected bowel was reconstructed with stapled end-to-end anastomosis. The surgical outcomes of this procedure were prospectively evaluated.
Results
The laparoscopic total mesorectal excision was performed with acceptable operation time (234.4±44.4 minutes, mean±standard deviation) and little blood loss (80.0±24.0 ml) through a small wound (5.0±0.5 cm). Histopathology showed that all patients were able to get adequate distal section margins (mean: 2.8 cm; range: 1.6–5.4 cm) and negative circumferential resection margins (mean: 8.4mm; range: 2–14 mm). The number of dissected lymph nodes was 16.0±4.0. The pathologic tumor–node–metastasis stages were as follows: Stage I: n= 4; Stage II: n = 22; Stage III: n = 18. Two patients (4.5 percent) were diverted by protective ileostomy. There was no mortality within 30 days after operation. However, anastomotic leakage occurred in 3 patients. The patients have quick functional recovery, as evaluated by the length of postoperative ileus (48.0±12.0 hours), hospitalization (9.0±1.0 days) and degree of postoperative pain (3.5±0.5, visual analog scale). Besides the expenses covered by the National Bureau of Health Insurance in Taiwan, the patient had to pay an extra expense of NT$ 65000.08000.0 (1.0US dollars = 32.0 NT$). During the follow-up periods (median: 14 months, range. 2 to 27 months), three patients of Stage III and 1 patient of Stage II developed a recurrent disease (lung metastasis: n = 2; liver metastasis: n = 1, and pelvic recurrence, n = 1).
Conclusion
By laparoscopic approach, the total mesorectal excision for rectal cancers can be safely performed with good functional recovery. However, with only a median follow-up of 14 months in this case series, the long-term oncologic outcomes for these patients remain a question. Further randomized prospective study is thus mandatory to provide solid evidence of this approach.
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References
RJ Heald EM Husband RD Ryall (1982) ArticleTitleThe mesorectum in rectal cancer surgery-the clue to pelvic recurrence? Br J Surg 69 613–616 Occurrence Handle1:STN:280:BiyD38zpsVU%3D Occurrence Handle6751457
J Leroy F Jamali L Forbes et al. (2004) ArticleTitleLaparoscopic total mesorectal excision (TME) for rectal cancer surgery Surg Endosc 18 281–289 Occurrence Handle1:STN:280:DC%2BD2c7kvFeluw%3D%3D Occurrence Handle14691716
AJ Pikarsky R Rosenthal EG Weiss SD Wexner (2002) ArticleTitleLaparoscopic total mesorectal excision Surg Endosc 16 558–562 Occurrence Handle1:STN:280:DC%2BD383jsVeksA%3D%3D Occurrence Handle11972187
JT Liang MJ Shieh CN Chen et al. (2002) ArticleTitleProspective evaluation of laparoscopy-assisted colectomy versus laparotomy with resection in the management of complex polyps of the sigmoid colon World J Surg 26 377–383 Occurrence Handle11865378
JT Liang HS Lai KC Huang et al. (2003) ArticleTitleComparison of medial-to-lateral versus traditional lateral-to-medial dissection sequences for the resection of rectosigmoid cancers—A randomized controlled clinical trial World J Surg 27 190–196 Occurrence Handle10.1007/s00268-003-1029-z Occurrence Handle12616435
JT Liang (2003) ArticleTitleComparison of medial-to-lateral versus traditional lateral-to-medial dissection sequences for the resection of rectosigmoid cancers [letter] World J Surg 27 1337–1338 Occurrence Handle10.1007/s00268-003-1029-z
JW Milsom B Böhm (1996) Laparoscopic Colorectal Surgery Springer-Verlag New York
JW Milsom B Böhm KA Hammerhofer et al. (1998) ArticleTitleA prospective, randomized trial comparing laparoscopic versus conventional techniques in colorectal cancer surgery: a preliminary report J Am Coll Surg 187 46–57 Occurrence Handle10.1016/S1072-7515(98)00132-X Occurrence Handle1:STN:280:DyaK1czitFClsw%3D%3D Occurrence Handle9660024
RG Beets-Tan (2003) ArticleTitleMRI in rectal cancer: the T stage and circumferential resection margin Colorectal Disease 5 392–395 Occurrence Handle10.1046/j.1463-1318.2003.00518.x Occurrence Handle1:STN:280:DC%2BD3szovVegsw%3D%3D Occurrence Handle12925068
InstitutionalAuthorNameJapanese Society for Cancer of the Colon and Rectum (1994) General Rules for Clinical and Pathological Studies on Cancer of the Colon, Rectum, and Anus Kanehara Tokyo
W Sjoerdsma DW Meijer A Jansen et al. (2000) ArticleTitleComparison of efficiencies of three techniques for colon surgery J Laparoendoscopic & Advanced Surgical Technique 10 47–53 Occurrence Handle1:STN:280:DC%2BD3c7mvVyhsg%3D%3D
E Bärlehner T Benhidjeb S Anders B Schicke (2005) ArticleTitleLaparoscopic resection for rectal cancer: Outcomes in 194 patients and review of the literature Surg Endosc 19 757–766 Occurrence Handle10.1007/s00464-004-9134-0 Occurrence Handle15868256
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Liang, JT., Lai, HS. & Lee, PH. Laparoscopic Total Mesorectal Excision for Rectal Cancers. Dis Colon Rectum 49, 517–518 (2006). https://doi.org/10.1007/s10350-005-0325-0
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DOI: https://doi.org/10.1007/s10350-005-0325-0