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Hypotheses explaining cancer metastasis

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The Chinese-German Journal of Clinical Oncology

Abstract

Cancer metastasis is the most important factor causing patients death. Cancer diseases will be controllable if metastasis does not happen. Concerning the mechanism of cancer metastasis, there are still many points to be clarified. Currently, the mechanism of cancer metastasis has been explained from several aspects of its biological behaviors. Here we briefly summarized some newly-developed metastasis models to provide a global glance at this topic.

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References

  1. Lisanti MP, Martinez-Outschoorn UE, Lin Z, et al. Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis: the seed and soil also needs “fertilizer”. Cell Cycle, 2011, 10: 2440–2449.

    Article  PubMed  CAS  Google Scholar 

  2. Aguirre-Ghiso JA. On the theory of tumor self-seeding: implications for metastasis progression in humans. Breast Cancer Res, 2010, 12: 304.

    Article  PubMed  Google Scholar 

  3. Langley RR, Fidler IJ. The seed and soil hypothesis revisited-the role of tumor-stroma interactions in metastasis to different organs. Int J Cancer, 2011, 128: 2527–2535.

    Article  PubMed  CAS  Google Scholar 

  4. Pece S, Tosoni D, Confalonieri S, et al. Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. Cell, 2010, 140: 62–73.

    Article  PubMed  CAS  Google Scholar 

  5. Setoguchi T, Taga T, Kondo T. Cancer stem cells persist in many cancer cell lines. Cell Cycle, 2004, 3: 414–415.

    Article  PubMed  CAS  Google Scholar 

  6. Kerosuo L, Bronner-Fraser M. What is bad in cancer is good in the embryo: Importance of EMT in neural crest development. Semin Cell Dev Biol, 2012, 23: 320–332.

    Article  PubMed  CAS  Google Scholar 

  7. Biddle A, Mackenzie IC. Cancer stem cells and EMT in carcinoma. Cancer Metastasis Rev, 2012 Feb 3 [Epub ahead of print].

  8. Deng JJ, Xu XM. Epithelial-mesenchymal transition and cancermetastasis. Chinese-German J Clin Oncol, 2011, 10: 125–133.

    Article  CAS  Google Scholar 

  9. Reddy BY, Lim PK, Silverio K, et al. The microenvironmental effect in the progression, metastasis, and dormancy of breast cancer: a model system within bone marrow. Int J Breast Cancer, 2012. 2012:721659.

    PubMed  Google Scholar 

  10. Karrison TG, Ferguson DJ, Meier P. Dormancy of mammary carcinoma after mastectomy. J Natl Cancer Inst, 1999, 91: 80–85.

    Article  PubMed  CAS  Google Scholar 

Download references

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Correspondence to Haili Qian.

Additional information

Supported by a grant from the National Natural Sciences Foundation of China (No. 81071773, 30973447, 30973471).

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Wang, H., Lin, C. & Qian, H. Hypotheses explaining cancer metastasis. Chin. -Ger. J. Clin. Oncol. 11, 689–690 (2012). https://doi.org/10.1007/s10330-012-1061-2

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  • DOI: https://doi.org/10.1007/s10330-012-1061-2

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