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Biochemical markers of bone turnover as predictors of osteoporosis and osteoporotic fractures in men and women: 10-year follow-up of the Taiji cohort

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Modern Rheumatology

Abstract

We aimed to assess the capacity of biochemical markers of bone turnover (BTMs) to predict bone loss, osteoporosis (OP), and osteoporotic fractures. We randomly selected 400 individuals (age 40–79 years in 1993; 50 of each gender and age stratum) from a list of registered residents. In the years 1993, 1996, 2000, and 2003, bone mineral density (BMD) of the spine and hip were measured by dual-energy X-ray absorptiometry. The BTMs assessed at baseline were serum intact osteocalcin (OC), total OC, bone-specific alkaline phosphatase, C-terminal propeptide of type I procollagen, N-terminal propeptide of type I procollagen (PINP), C-terminal cross-linking telopeptide of type I collagen generated by matrix metalloproteinase, C-terminal cross-linking telopeptide of type I collagen (beta-CTX), N-terminal cross-linking telopeptide of type I collagen (NTX), urinary pyridinoline, and deoxypyridinoline (DPD). For 307 completers, multivariate analysis after adjusting for confounders revealed that serum PINP levels in men [hazard ratio (HR) 2.80, P < 0.05] and serum PINP (HR 1.65, P < 0.05), beta-CTX (HR 1.80, P < 0.001), NTX (HR 1.96, P < 0.01), and urinary DPD levels (HR 1.40, P < 0.05) in women were significantly related to the occurrence of spinal OP. In addition to adjustment for the baseline status of BMD, i.e., osteopenia or normal range, PINP, beta-CTX, and NTX in women could significantly predict the future occurrence of spinal OP. BTMs were not significant predictors of bone loss, femoral OP, or osteoporotic fractures. In conclusion, various BTMs in women can predict the occurrence of spinal OP.

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Acknowledgments

This work was supported by Grants-in-Aid for Scientific Research: B20390182 (Noriko Yoshimura), C20591737 (Toru Akune), C20591774 (Shigeyuki Muraki), and Young Scientists A18689031 (Hiroyuki Oka) and Collaborating Research with NSF 08033011-00262 (Director, Noriko Yoshimura) from the Ministry of Education, Culture, Sports, Science and Technology, H17-Men-eki-009 (Director, Kozo Nakamura), H18-Choujyu-037 (Director, Toshitaka Nakamura) and H20-Choujyu-009 (Director, Noriko Yoshimura) from the Ministry of Health, Labour and Welfare in Japan. This study was also supported by grants from the Japan Osteoporosis Society (Noriko Yoshimura), Nakatomi Foundation (Noriko Yoshimura), and research aid from the Japanese Orthopaedic Association. The sponsors had no role in the study design, data collection, data analysis, data interpretation, or writing of the report. The authors wish to thank Mrs. Tamako Tsutsumi, Mrs. Kanami Maeda, and other staff of the Public Office in Taiji Town and the staff of the Public Health Center in Shingu City for assistance with the location of participants and examination scheduling.

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Authors and Affiliations

  1. Department of Joint Disease Research, 22nd Century Medical and Research Center, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Noriko Yoshimura & Hiroyuki Oka

  2. Department of Clinical Motor System Medicine, 22nd Century Medical and Research Center, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

    Shigeyuki Muraki & Toru Akune

  3. Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

    Hiroshi Kawaguchi & Kozo Nakamura

Authors
  1. Noriko Yoshimura
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  2. Shigeyuki Muraki
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  3. Hiroyuki Oka
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  4. Hiroshi Kawaguchi
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  5. Kozo Nakamura
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  6. Toru Akune
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Correspondence to Noriko Yoshimura.

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Yoshimura, N., Muraki, S., Oka, H. et al. Biochemical markers of bone turnover as predictors of osteoporosis and osteoporotic fractures in men and women: 10-year follow-up of the Taiji cohort. Mod Rheumatol 21, 608–620 (2011). https://doi.org/10.1007/s10165-011-0455-2

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  • DOI: https://doi.org/10.1007/s10165-011-0455-2

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