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Epidemiology of lumbar osteoporosis and osteoarthritis and their causal relationship—is osteoarthritis a predictor for osteoporosis or vice versa?: The Miyama study

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Abstract

Summary

In a 10-year follow-up of a population-based cohort of Japanese subjects, incidences of and causal relationships between osteoporosis (OP) and osteoarthritis (OA) at the lumbar spine were clarified. OP might reduce the risk of subsequent OA at the spine in women, but not in men.

Introduction

The aim of this study is to clarify the contribution of osteoarthritis (OA) to osteoporosis (OP) and vice versa.

Methods

A population-based, epidemiological study was conducted in a Japanese rural community. From 1,543 participants aged 40–79 years, 200 men and 200 women were selected and followed up for 10 years. Bone mineral density measurements were repeated after 3, 7, and 10 years, and X-rays were repeated after 10 years.

Results

The incidence of lumbar OP per 10,000 person-years for persons in their 40s, 50s, 60s, and 70s was 0, 0, 109.5, and 151.1 for men and 124.2, 384.0, 227.3, and 239.5 for women, respectively. The cumulative incidence of lumbar OA over 10 years aged 40–79 years was 25.8% in men and 45.2% in women. Cox’s proportional hazards model showed no significant relationship between the presence of lumbar OA at the baseline and incidence of lumbar and femoral neck OP in both genders. A significant relationship was demonstrated between the presence of lumbar OP, not femoral neck OP, at the baseline and cumulative incidence of lumbar OA in women (odds ratio, 0.20; 95% confidence interval, 0.05–0.80; P = 0.02).

Conclusion

OP in women appears to reduce the future incidence of OA at the lumbar spine.

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Acknowledgments

This study was supported by Grants-in-Aid for Scientific Research B20390182 (Noriko Yoshimura), C20591737 (Toru Akune), C20591774 (Shigeyuki Muraki), Young Scientists A18689031 (Hiroyuki Oka), and Collaborating Research with NSF 08033011-00262 (Noriko Yoshimura) from the Ministry of Education, Culture, Sports, Science and Technology, H17-Men-eki-009 (Director, Kozo Nakamura), H18-Choujyu-037 (Director, Toshitaka Nakamura), and H20-Choujyu-009 (Director, Noriko Yoshimura) from the Ministry of Health, Labour and Welfare in Japan. This study was also supported by grants from the Japan Osteoporosis Society, Japan Health Foundation, Nakatomi Foundation (Noriko Yoshimura), and research aid from the Japanese Orthopaedic Association (Director, Hiroshi Kawaguchi). The authors wish to thank Mrs. Tomoko Takijiri, Mrs. Kumiko Shinou, Mr. Kenji Kubo, and other members in the public office in Miyama village for their assistance and scheduling participants for examinations.

Conflicts of interest

None.

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Authors and Affiliations

  1. Department of Joint Disease Research, 22nd Century Medical and Research Center, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    N. Yoshimura & H. Oka

  2. Department of Clinical Motor System Medicine, 22nd Century Medical and Research Center, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

    S. Muraki & T. Akune

  3. Department of Human Genetics, Graduate School of International Health, The University of Tokyo, Tokyo, Japan

    A. Mabuchi

  4. Department of Orthopaedic Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan

    H. Kinoshita & M. Yosihda

  5. Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

    H. Kawaguchi & K. Nakamura

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  1. N. Yoshimura
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  2. S. Muraki
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  3. H. Oka
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  4. A. Mabuchi
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  5. H. Kinoshita
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  7. H. Kawaguchi
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  8. K. Nakamura
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  9. T. Akune
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Corresponding author

Correspondence to N. Yoshimura.

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Yoshimura, N., Muraki, S., Oka, H. et al. Epidemiology of lumbar osteoporosis and osteoarthritis and their causal relationship—is osteoarthritis a predictor for osteoporosis or vice versa?: The Miyama study. Osteoporos Int 20, 999–1008 (2009). https://doi.org/10.1007/s00198-008-0771-3

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  • DOI: https://doi.org/10.1007/s00198-008-0771-3

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