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Circular RNAs: a small piece in the heart failure puzzle

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Abstract

Cardiovascular disease, specifically heart failure (HF), remains a significant concern in the realm of healthcare, necessitating the development of new treatments and biomarkers. The RNA family consists of various subgroups, including microRNAs, PIWI-interacting RNAs (piRAN) and long non-coding RNAs, which have shown potential in advancing personalized healthcare for HF patients. Recent research suggests that circular RNAs, a lesser-known subgroup of RNAs, may offer a novel set of targets and biomarkers for HF. This review will discuss the biogenesis of circular RNAs, their unique characteristics relevant to HF, their role in heart function, and their potential use as biomarkers in the bloodstream. Furthermore, future research directions in this field will be outlined. The stability of exosomal circRNAs makes them suitable as biomarkers, pathogenic regulators, and potential treatments for cardiovascular diseases such as atherosclerosis, acute coronary syndrome, ischemia/reperfusion injury, HF, and peripheral artery disease. Herein, we summarized the role of circular RNAs and their exosomal forms in HF diseases.

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Authors and Affiliations

  1. Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran

    Reza Eshraghi & Arash Raisi

  2. Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

    Davood Shafie

  3. Department of Genetics, Faculty of Biology, Sana Institute of Higher Education, Sari, Iran

    Pouya Goleij

  4. USERN Office, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Pouya Goleij

  5. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran

    Hamed Mirzaei

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RE, DS, AR, and PG, and HM contributed in the conception, design and drafting of the manuscript. All authors approved the final version for submission.

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Eshraghi, R., Shafie, D., Raisi, A. et al. Circular RNAs: a small piece in the heart failure puzzle. Funct Integr Genomics 24, 102 (2024). https://doi.org/10.1007/s10142-024-01386-z

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